BIGH3基因在角膜疾病及糖尿病视网膜病变中的研究新进展  

Latest progress of BIGH3 gene in corneal diseases and diabetic retinopat hy

作　　者：宋凡倩 高宁宁[1] 葛红岩[1] 

机构地区：[1]哈尔滨医科大学第一临床学院眼科医院,中国黑龙江省哈尔滨市150001

出　　处：《国际眼科杂志》2017年第3期449-450,共2页International Eye Science

基　　金：国家自然科学青年基金项目(No.81300728);黑龙江省教育厅面上项目(No.12541516)~~

摘　　要：BIGH3基因在眼部疾病中起重要作用。一方面,与角膜疾病的发生息息相关,BIGH3基因可以抑制角膜新生血管形成,导致角膜营养不良,参与圆锥角膜形成;另一方面,可以导致糖尿病视网膜病变中新生血管的生成,有最新实验证明,巨噬细胞分泌的TGFβ可以促进BIGH3 mRNA和BIGH3蛋白的表达,并促进视网膜内皮细胞和周细胞凋亡,从而导致糖尿病视网膜病变新生血管的形成。本文将从如上几个方面阐述BIGH3基因在眼部疾病研究的新进展。BIGH3 gene plays an important role in ocular diseases.On the one hand,it is closely related to the occurrence of corneal diseases.BIGH3 gene can inhibit corneal neovascularization,lead to corneal dystrophy,participate in keratoconus formation.On the other hand,it can lead to the formation of neovascularization in diabetic retinopathy.The latest experiments show that TGF beta secreted by macrophages can promote the expression of BIGH3 mRNA and BIGH3 protein,and promote apoptosis of retinal endothelial cells and pericytes,which leads to the formation of neovascularization in diabetic retinopathy.This article will describe the new progress of BIGH3 gene in ocular diseases from several aspects as mentioned above.

关 键 词：BIGH3 角膜新生血管 角膜营养不良 圆锥角膜 糖尿病视网膜病变 

分 类 号：R772.2[医药卫生—眼科] R587.2[医药卫生—临床医学] R774.1