华蟾素注射液辅助西妥昔单抗注射液交替化疗对胸段食管癌淋巴结转移患者的疗效及安全性评估  

Clinical Effects and Safety of Cinobufotalin Injection Assisted Cetuximab Injection Alternating Chemotherapy in the Treatment of Lymph Node Metastasis of Thoracic Esophageal Cancer

作　　者：冯慧[1] 王华[1] 张晓彦[1] 王国庆[1] 付兴[1] 

机构地区：[1]北京市平谷区医院肿瘤科,北京101200

出　　处：《肿瘤药学》2017年第1期93-98,共6页Anti-Tumor Pharmacy

摘　　要：目的探讨华蟾素注射液辅助西妥昔单抗交替化疗治疗胸段食管癌淋巴结转移患者的疗效及安全性。方法选择我院肿瘤内科收治的胸段食管癌淋巴结转移患者78例,按随机数字表法分为两组,每组各39例。对照组在放疗基础上予以化疗治疗,研究组在放疗基础上予以华蟾素注射液辅助西妥昔单抗与化疗方案交替治疗,检测和比较两组治疗前后肿瘤坏死因子(TNF-α)、白介素-6(IL-6)、白介素-8(IL-8)、一氧化氮(NO)、血管内皮生长因子(VEGF)、癌抗原CAl25(CAl25)、癌抗原CAl99(CAl99)及癌胚抗原(CEA)水平,记录两组毒副作用的发生情况,比较其临床疗效和2年、3年生存率。结果与治疗前比较,两组治疗后TNF-α、IL-6、IL-8、VEGF、CAl25、CAl99及CEA水平降低,NO水平、躯体、角色、社会、情绪、认知等生活质量评分升高(P<0.05);与对照组比较,研究组治疗后TNF-α、IL-6、IL-8、VEGF、CAl25、CA199及CEA水平较低,NO水平、躯体、角色、社会、情绪、认知等生活质量评分较高(P<0.05)。对照组有效率为69.23%,显著低于研究组的89.74%(P<0.05)。研究组患者2年、3年生存率明显高于对照组(P<0.05);两组间不良反应发生率比较差异无统计学意义(P>0.05)。结论华蟾素注射液辅助西妥昔单抗交替化疗对胸段食管癌淋巴结转移患者疗效确切,可显著提高患者的生活质量,且安全性高。Objective To evaluate the clinical effects and safety of Cinobufotalin injection-assisted Cetuximab injection alternating chemotherapy in the treatment of lymph node metastasis of thoracic esophageal cancer. Methods Seventy-eight patients with lymph node metastasis of thoracic esophageal carcinoma treated in our department of oncology were selected in this study. All patients were randomly divided into two groups. Each group had 39 cases. The control group received chemotherapy based on radiotherapy, and the study group re- ceived Cinobufotalin injection auxiliary cetuximab alternating chemotherapy on the basis of radiotherapy. Detect and compare the levels of TNF-α, IL-6, IL-8, NO, VEGF, CA125, CA199 and CEA before and after treatment between the two groups. Record the incidence of side effects of two groups, and compare the clinical curative effect and 2-year and 3-year survival rate. Results Compared with before treatment, the levels of TNF-α, IL-6, IL-8, VEGF, CA125, CA199 and CEA were decreased, while the levels of NO was increased, and the scores of body, role, society, emotion and cognition were increased after treatment in both groups（P〈 0.05）. After treatment, the levels of TNF-α, IL-6, IL-8, VEGF, CA125, CA199 and CEA were lower, while the levels of NO and scores of body, role, society, emotion and cognition were higher in the study group than in the control group（P〈0.05）. The effective rate in the study group（89.74%）was significantly higher than in the control group（69.23%）（P〈 0.05）. The 2-year and 3-year survival rates in the study group were significantly higher than in the control group（P〈0.05）. There was no statistical difference in the incidence of adverse reactions between the two groups（P〉 0.05）. Conclusion The Cinobufotalin injection assisted Cetuximab injection alternating chemotherapy was effective in the treatment of lymph node metastasis of thoracic esophageal cancer. It could not only enhance the quality of life, but also improve the safety.

关 键 词：华蟾素注射液 西妥昔单抗 化疗 胸段食管癌淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]