大肠癌淋巴结微转移检测的研究进展  

Progress in detection of lymph node metastasis in colorectal cancer

作　　者：段金雨 刘春雷[1] 贾宝洋[1] 关晓辉[1] 

机构地区：[1]北华大学附属医院消化科,吉林省吉林市132000

出　　处：《世界华人消化杂志》2017年第3期261-266,共6页World Chinese Journal of Digestology

摘　　要：大肠癌是最常见的恶性肿瘤之一,其在我国的发病率和死亡率有逐年上升的趋势.随着大肠癌根治术及辅助治疗手段的不断改进,总体预后有一定改善,但接受根治术的患者5年内仍有20%-40%死于肿瘤的复发及转移,尤其是淋巴结转移.淋巴结转移是以淋巴结微转移为基础的.因此,预测和诊断淋巴结微转移对患者的预后和治疗具有十分重要的意义.随着分子生物技术的发展,尤其是逆转录多聚酶链反应技术的成熟,使淋巴结微转移的检测已成为目前研究的热点.Colorectal cancer is one of the most common malignant tumors,and its morbidity and mortality have a rising trend in China.The continuous improvement of surgery and adjuvant therapy for colorectal cancer has improved the overall prognosis,but 40%-50%of patients undergoing radical resection still die of tumor recurrence and metastasis,especially lymph node metastasis.Lymph node metastasis results from lymph node micrometastasis.Therefore,the prediction and diagnosis of lymph node micrometastasis have very important significance in the prognosis evaluation and treatment of colorectal cancer patients.With the development of molecular biological technology,especially the reverse transcriptase polymerase chain reaction technology,the detection of lymph node micrometastasis has become a hot research topic.

关 键 词：大肠癌 淋巴结微转移 研究进展 逆转录多聚酶链反应 

分 类 号：R735.34[医药卫生—肿瘤]