ADRB1和ADRB2基因多态性与妊高症易感性的相关性  

Study on the relationship between genetic polymorphisms of ADRB1 and ADRB2 and pregnancy-induced hypertension

作　　者：程龙飞[1] 潘琼[1] 钮慧远[1] 金鑫[1] 张峰婷 李晓琼[1] 徐金霞[1] 张丽萍[1] 宁颖[1] 

机构地区：[1]淮安市妇幼保健院,江苏淮安223002

出　　处：《中国优生与遗传杂志》2017年第2期18-21,共4页Chinese Journal of Birth Health & Heredity

基　　金：江苏省妇幼健康科研项目(F201670);淮安市科技支撑计划项目(HAS2009003)

摘　　要：目的探讨ADRB1基因上的rs1801253位点和ADRB2基因上的rs1042711,rs1042713和rs1042714单核苷酸多态性位点与妊高征发病风险的相关性。方法病例组包括在我院产科住院的重度子痫前期患者284例,轻度子痫前期患者111例,以及其他妊高征109例,选择同期正常妊娠孕妇317例作为正常对照组,采用基质辅助激光解吸附电离飞行时间质谱进行基因分型。结果将病例组与健康对照组进行关联分析发现rs1042711,rs1042713和rs1801253三个位点在两者之间并没有发现显著性差异。rs1042714位点在病例组、重度子痫前期组以及子痫前期组(包括轻度子痫前期和重度子痫前期)分别与健康对照组进行关联分析发现存在显著性差异(P<0.5),但在其他妊高征患者中未发现有显著性差异。结论本研究发现ADRB2基因rs1042714位点可能与轻度子痫前期和重度子痫前期发病风险之间存在相关性。Objective：Pregnancy-induced hypertension（PIH）is a serious threat to the health of maternal and child. Here,we present a statistical analysis of rs1801253 of ADRB1 gene and rs1042711,rs1042713 and rs1042714 of ADRB2 gene to investigate the relationship between PIH and normotensive pregnant women. Methods：284 cases of severe preeclampsia patients,111 cases of mild preeclampsia,109 cases of PIH and 317 healthy pregnant women was chosen from Huai′an maternal and child health care hospital;using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry（MALDI-TOF MS）to investigate whether rs1801253,rs1042711,rs1042713 and rs1042714 are associated with PIH. Results：No significant difference of rs1042711,rs1042713 and rs1801253 were found out between case group and healthy control group. However,there was significant differences of rs1042714 between case group and healthy control group（P〈0.5）. Conclusion：Rs1042714 of gene ADRB2 may be associated with the risk of mild preeclampsia and severe preeclampsia.

关 键 词：妊娠高血压综合征 子痫前期 ADRB1基因 ADRB2基因 多态性 

分 类 号：R714.246[医药卫生—妇产科学]