934例不孕不育女性染色体异常核型分析及临床意义  

Clinical value of analysis on chromosome abnormality in peripheral blood lymphocytes of 934 cases of female patients with infertility

作　　者：黄丽婵 李九凤 乔伶俐 陈亚军 

机构地区：[1]韶关市妇幼保健院产前诊断中心,广东韶关512026

出　　处：《中国优生与遗传杂志》2017年第2期60-61,130,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨染色体异常对女性不孕不育的临床意义。方法对934例,年龄17~45岁不孕不育女性采集外周血进行淋巴细胞培养,制备染色体并分析染色体核型。结果 934例不孕不育女性外周血细胞核型分析,共检出异常核型23例,异常发生率为2.46%(23/934),按不孕(原发和继发)、习惯性流产、不良生育史、其他(胚停等)为4组,每组染色体异常发生率分别为2.52%(11/437)、4.55%(7/154)、4.23%(3/71)、0.74%(2/272),差异有统计学意义,P<0.05。结论染色体异常可导致不孕不育,提示不孕不育与遗传因素密切相关。Objective：To investingate the relation of female acyesis and chromosome abnormality. Methods：Cytogenetical analyze in 934 female acyesis patients age 17-45 years old. Prepare chromosome samples according to method use peripheral blood.G banding,the mode and karyotype analysis were adopted. Results：23 abnormal karyotypes were detected.The incident of the chromosome abnormality was 2.46%（23/934）.The incidence of fetal chromosomal abnormalities was significantly highest in habitual abortion group than that infertility group,abnormal gestation group and the rest group（P〉0.05）.Conclusion：Chromosome abnormality can lead to infertility,Genetic factors play an important role in the infertility.

关 键 词：不孕不育 核型分析 染色体异常 临床意义 

分 类 号：R711.6[医药卫生—妇产科学]