饮茶与牙龈癌发病关系的病例对照研究  

Association Between Tea Consumption and Risk of Gingival Carcinoma: A Case-control Study

作　　者：刘凤琼[1,2] 鄢灵君 陈法[1] 黄江峰[1] 刘芳萍[1] 邱宇[3] 林李嵩[3] 郑晓燕[3] 伍俊锋 何保昌[1,2] 

机构地区：[1]福建医科大学公共卫生学院流行病与卫生统计学系,福州350108 [2]福建医科大学公共卫生学院环境因素与肿瘤福建省重点实验室,福州350108 [3]福建医科大学附属第一医院口腔颌面外科,福州350004

出　　处：《肿瘤防治研究》2017年第2期138-141,共4页Cancer Research on Prevention and Treatment

基　　金：中央财政支持地方高校发展专项资金环境与健康表观遗传学研究创新团队项目(1003-03900130);福建省教育厅资助省属高校项目(JK2015017);福建省科技厅科研项目(2015J01304)

摘　　要：目的探讨饮茶对牙龈癌发病的影响。方法采用病例对照的研究方法,病例组为2 0 1 0年1 2月—2 0 1 6年3月经病理确诊的牙龈癌新发病例1 2 1例,同期经性别、年龄成组匹配,选取医院体检人群及社区健康人群363例作对照。应用非条件Logistic回归模型计算饮茶及其相关变量与牙龈癌发病风险的调整比值比(OR)及其95%置信区间(CI)并进行相乘交互作用分析。结果饮茶可降低牙龈癌的发病风险(OR=0.51,95%CI:0.29~0.90);进一步分析发现随着每日饮茶量的增加、饮茶年限的延长,牙龈癌的发病风险也随之降低(均Ptrend<0.05);此外饮茶年龄≥25岁、饮茶浓度适中、饮温茶以及饮绿茶和乌龙茶也可降低牙龈癌的发病风险。分层分析结果发现与吸烟者相比,在非吸烟者中饮茶的保护作用更加显著(OR=0.40,95%CI:0.1 7~0.9 6),在非饮酒和饮酒者中饮茶的保护作用差异则没有统计学意义。交互作用结果并未发现吸烟与饮茶,饮酒与饮茶之间存在相乘交互作用。结论饮茶是牙龈癌发病的保护因素,且每日饮茶量、饮茶年限与牙龈癌发病风险之间呈剂量反应关系。Objective To assess the effect of tea consumption on incidence of gingival carcinoma. Methods A case-control study including 121 gingival carcinoma patients confirmed by pathological diagnoses and 363 gender-age frequency matched controls were enrolled in Fujian province from December 2010 to March 2016. Unconditional logistic regression was used to calculate adjusted odds ratios（ORs） and corresponding 95% confidence intervals（CIs） to assess the effects of tea related variables on gingival carcinoma and interaction analysis. Results Tea consumption was associated with decreased risk of gingival carcinoma（OR=0.51, 95%CI： 0.29-0.75）. Moreover, with a greater daily quantity and a longer duration of tea-drinking, the risk of gingival carcinoma was reduced（all Ptrend0.05）. Furtherly, age of tea drinking initiation（years） more than 25, moderate concentration as well as temperature of tea, drinking green tea and oolong tea were also showed decreased the risk of gingival carcinoma. The stratificated analysis indicated that the protective effect of tea drinking was more evident among non-tobacco smokers（OR=0.40, 95%CI： 0.17-0.96）, but no significance was observed in the alcohol drinkers or non-alcohol drinkers. No significantly multiplicative interaction was observed between smoking and tea. The same result was found between alcohol drinking and tea. Conclusion Tea consumption plays a protective effect on gingival carcinoma. Moreover, there is dose-response relationship between daily quantity or duration of tea-drinking and risk of gingival cancer.

关 键 词：牙龈癌 饮茶 病例对照研究 

分 类 号：R739.82[医药卫生—肿瘤]