钙类纳米粒子基因传递体系研究进展  

Advances in Calcium Based Nanoparticles for Gene Delivery

作　　者：艾书伦[1] 程巳雪[1] 

机构地区：[1]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《武汉大学学报（理学版）》2017年第1期1-8,共8页Journal of Wuhan University:Natural Science Edition

基　　金：国家自然科学基金(21274113)资助项目

摘　　要：作为一类重要的非病毒基因载体,钙类纳米粒子如磷酸钙、碳酸钙等因具有理想的生物相容性和生物降解性而备受关注.本文根据近年来钙类纳米粒子基因传递体系的研究进展,着重评述了通过钙类纳米粒子基因传递体系形貌和结构优化、组分调控及其功能化等来提高基因传递效率方面的研究工作.Among various non-viral gene vectors, calcium based nanoparticles, such as nano-sized calcium phos- phate and calcium carbonate, have attracted increasing research interest due to their ideal biocompatibility and biode- gradability. In this article, the recent advances in nano-sized calcium based gene delivery systems are reviewed, with the emphasis on the research efforts to achieve improved gene delivery efficiency and diverse functions by the optimiza- tion of the morphology and structure of the calcium based nanoparticles and preparation of multi-component gene deliv- ery systems.

关 键 词：基因传递 纳米粒子 磷酸钙 碳酸钙 杂化材料 功能化 

分 类 号：O63[理学—高分子化学]