食管癌切除术术前风险评分(PRSEC)与预后的关系  

Relationship between preoperative risk score for esophageal cancer(PRSEC) and prognosis after resection of esophageal carcinoma

作　　者：马建兴[1] 冯海明[1] 敬涛[1] 李斌[1] 王成[1] 张建华[1] 

机构地区：[1]兰州大学第二医院胸外科,兰州730000

出　　处：《中国胸心血管外科临床杂志》2017年第3期188-191,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：甘肃省自然科学基金项目资助(145RJZA137)

摘　　要：目的探讨食管癌术术前风险评分(PRSEC)与食管癌切除术后患者预后的关系。方法回顾性分析2005~2015年我院行食管癌切除术的498例食管癌患者的临床资料,其中男392例、女106例,中位年龄59(30~83)岁。通过术前风险评分(修订的心脏风险指数、终末期肝病模型评分和肺功能测试评分)将患者分为3组:PRSEC1组,PRSEC2组和PRSEC3组,计算总体生存期(OS)和无病生存期(DFS),分析术前风险评分与患者预后的关系。结果患者的死亡率、发病率、DFS及OS都与食管癌切除术前评分有关。对于行食管癌切除术的患者,食管癌切除术术前评分可以清楚地预测其短期的治疗效果。评分为2分和3分的患者死亡率和发病率的风险显著高于1分的患者。另外,评分高的患者DFS和OS更短(P<0.001)。结论食管癌切除术前风险评分评分方式简便易行,能客观地反映患者发病率、死亡率、长期治疗效果。Objective To introduce a simple preoperative risk score for esophageal cancer （PRSEC） and its relationship with the prognosis of patients who underwent resection of esophageal carcinoma. Methods We retrospectively analyzed the clinical data of 498 patients receiving resection of esophageal carcinoma between 2005 and 2015 in our hospital. They were divided into three groups （PRSEC1, PRSEC2 and PRSEC3 groups） according to the results of PRSEC （revised cardiac risk index, model for end-stage liver disease score and pulmonary function test）. Their overall survival （OS） and disease-free survival （DFS） were measured to find the relationship between the PRSEC and prognosis of patients. Results The mortality, morbidity, DFS and OS were correlative with the PRSEC. Therefore the PRSEC can be used to predict the short-term outcome. The patients with score 2 or 3 had higher risk of mortality and morbidity than those with score 1. In addition, the DFS and OS of patients with higher score were shorter （P〈0.001）. Conclusion The PRSEC is easy and efficient and can predict the morbidity, mortality, and long-term outcomes for the patients with resection of esophageal carcinoma.

关 键 词：食管癌 食管癌术前风险评分 食管癌切除术 回顾性研究 

分 类 号：R735.1[医药卫生—肿瘤]