神经内分泌变化与帕金森病的相关性  

Correlation between neuroendocrine changes and Parkinson' s disease

作　　者：吕燕[1] 田玉玲[1] 

机构地区：[1]山西医科大学第一医院神经内科,太原030001

出　　处：《中华脑科疾病与康复杂志（电子版）》2016年第3期158-160,共3页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

摘　　要：帕金森病多见于中老年人,是一种常见的神经系统变性疾病。帕金森病痴呆指帕金森病患者认知功能损害达到痴呆的程度,研究帕金森病痴呆发生的危险因素对帕金森病痴呆的治疗及改善预后具有重要意义。目前有研究表明,亚临床甲状腺功能减退对帕金森病痴呆有一定影响,胰岛素抵抗与帕金森病痴呆有密切的关系,血皮质醇水平同年龄相关的认知功能下降密切相关,雌激素对帕金森病有保护作用。不同研究对神经内分泌与帕金森病的相关性存在争议,本文对帕金森病与甲状腺功能、胰岛素抵抗、血皮质醇水平及雌激素水平的相关性进行探讨。Parkinson＇ s disease（ PD） is a common neurodegenerative disease in the elderly. PD dementia refers to the degree of cognitive impairment to dementia. Risk factors of PD dementia is of great significance to improve the treatment and prognosis of it. Many researches showed that subclinical hypothyroidism and insulin resistance had a certain influence on PD dementia. They were also confirmed that the serum cortisol level was closely related to the age-related cognitive impairment,the estrogen had a protective effect against PD. It is controversial that the relationship between neuroendocrine and PD. We discussed the relationship between them.

关 键 词：帕金森病 痴呆 甲状腺功能减退症 雌激素类 胰岛素抵抗 皮质醇 

分 类 号：R742.5[医药卫生—神经病学与精神病学]