中西医结合疗法治疗溃疡性结肠炎的疗效及对凝血功能、炎性因子水平的影响分析  

Analysis on the therapeutic effects of Integrated Traditional Chinese and Western Medicine on ulcerative colitis and its effects on coagulation function and inflammatory factors

作　　者：朱颖玲[1] 唐晓华[1] 吴红铃[1] 

机构地区：[1]江苏省盐城市第三人民医院,江苏盐城224006

出　　处：《中国医药科学》2016年第23期82-86,共5页China Medicine And Pharmacy

摘　　要：目的分析中西医结合疗法治疗溃疡性结肠炎的疗效及对凝血功能、炎性因子水平的影响。方法选取UC活动期患者200例作为研究对象,将其随机分为观察组和对照组,每组100例。对照组患者采用单纯西药治疗,观察组患者在对照组疗法基础上加用中药灌肠治疗。对两组患者的临床疗效进行评价和比较。对两组患者治疗前、后的活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、血浆纤维蛋白原(Fib)、D二聚体(D-D)等凝血功能指标进行检测和比较。对两组患者的血清肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素(IL-8)水平进行测定和比较。结果观察组和对照组的临床有效率分别为96%和76%,观察组的临床有效率和疗效均优于对照组,两组之间有统计学意义(P<0.05)。两组患者治疗后的血浆Fib水平和血浆D-D水平均较治疗前显著降低,差异有统计学意义(P<0.05),而且观察组患者治疗后的血浆Fib水平和血浆D-D水平均低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后各项血清炎性因子水平均较治疗前显著降低,差异有统计学意义(P<0.05),而且观察组患者治疗后的各项血清炎性因子水平均低于对照组,差异有统计学意义(P<0.05)。结论应用中西医结合疗法治疗UC,能够显著提高治疗效果,纠正患者的凝血纤溶功能失衡,降低炎症反应程度,有利于促进患者康复、减少并发症、改善患者的预后。Objective To analyze the therapeutic effects of Integrated Traditional Chinese and Western Medicine on ulcerative colitis（UC） and its effects on coagulation function and inflammatory factors. Methods 200 cases of patients with UC were selected as the research subjects and randomly divided into the observation group and the control group,100 cases were included into each group.The patients in the control group were treated with single western medicine,while the patients in the observation group were treated with enema treatment of traditional Chinese Medicine.The clinical therapeutic effects of the two groups were evaluated and compared.The blood coagulation indexes of the activated partial thromboplastin time（APTT）,prothrombin time（PT）,the plasma fibrinogen（Fib）,the D dimer（D-D） before and after the treatment of the patients in the two groups were detected and compared.The serum tumor necrosis factor α（TNF-α）,interleukin-6（IL-6）,interleukin-8（IL-8） levels of the patients in the two groups were measured and compared. Results： The clinical efficiencies of the observation group and the control group were 96% and 76%,the clinical efficiencies and the therapeutic effects of the observation group were better than those in the control group,there were statistically significant differences between the two groups（P〈0.05）.The plasma Fib levels and the plasma D-D levels after the treatment of the patients in the two groups were significantly lower than those before the treatment,the difference was statistically significant（P〈0.05）.The plasma Fib levels and the plasma D-D levels after the treatment of the patients in the observation group were lower than those in the control group, the difference was statistically significant（P〈0.05）.The serum inflammatory factors levels after the treatment of the patients in the two groups were significantly lower than those before the treatment, the difference was statistically significant（P〈0.05）.The serum inflammatory factors le

关 键 词：中西医结合疗法 溃疡性结肠炎 疗效观察 凝血功能 炎性因子 

分 类 号：R574.62[医药卫生—消化系统]