多囊卵巢综合征对孕期产前筛查的影响  

Influence of PCOS to pregnancy prenatal screening

作　　者：张锐[1] 贺小红[1] 杨晓华[1] 

机构地区：[1]深圳市宝安区妇幼保健院产前诊断中心,广东深圳518133

出　　处：《中国医药科学》2016年第24期78-80,共3页China Medicine And Pharmacy

基　　金：广东省深圳市宝安区卫生公益性科研项目(2013080)

摘　　要：目的研究多囊卵巢综合征对孕早、中期各项筛查指标的影响,探讨多囊卵巢综合征合并妊娠的孕妇孕期产前筛查结果的可靠性。方法选取2014年7月~2015年10月在我院产检的单胎妊娠合并多囊卵巢综合征的96例孕妇作为实验组,同时随机选取该时间段在我院产检的100例无多囊卵巢综合征病史的孕妇作为对照组,孕早期(11~13^(+6)周)检测血清妊娠相关血浆蛋白A(PAPP-A)和游离β-人绒毛膜促性腺激素(fβ-HCG)以及对胎儿颈项透明层(NT)进行测量(12~13周),孕中期(15~20^(+6)周)检测fβ-HCG,甲胎蛋白(AFP)和游离雌三醇(u E3)。分别比较两组孕妇的血清学生化指标及NT值。结果孕早期实验组中PAPP-A及fβ-HCG的中位数倍数(MOM值)显著低于对照组(P<0.05),唐氏综合征风险预测值显著高于对照组(P<0.05);实验组及对照组NT值差异无统计学意义(P>0.05)。孕中期实验组中fβ-HCG的MOM值显著低于对照组(P<0.05);实验组及对照组中AFP和u E3的MOM值及唐氏综合征风险预测值差异无统计学意义(P>0.05)。结论多囊卵巢综合症孕妇孕期血清PAPP-A及fβ-HCG的MOM值明显偏低,降低了产前筛查准确性,提高了早期唐氏综合征筛查的假阳性率。Objective To investigate the influence of PCOS on the first and second-trimester combined aneuploidy screening test of pregnantand,and to explore the reliability of the screening to pregnant women with PCOS. Methods 96 cases of single pregnancy with a history of PCOS from July 2014 to October 2015 were selected as study group,and 100 cases of single pregnancy without a history of PCOS over the same time were randomly selected as control group.The PAPP-A,fβ-HCC and fetal nuchal translucency were compared between the two groups during the first-trimester（11 13＋6 weeks）,and the fβ-HCG,AFP and u E3 were compared between the two groups during second–trimester（15 20＋6 weeks）.Serum biochemical parameters and NT values of two groups were compared. Results The median number of PAPP-A and f beta-HCG（MOM）in the experimental group was significantly lower than that in the control group（P 〈 0.05）,and the risk of Down syndrome was significantly higher than that of the control group（P 〈 0.05）.There was no significant difference in NT value between the experimental group and the control group（P 〉 0.05）.The MOM value of F beta-HCG in the experimental group was significantly lower than that in the control group（P 〈 0.05）.The MOM values of AFP and u E3 in the experimental group and the control group had no significant difference（P 〉0.05）. Conclusion The levels of PAPP-A and fβ-HCC in single pregnancy with PCOS are lower,which will decrease the reliability of the first and second trimester combined aneuploidy screening test and increase the false positive rate for down syndrome.

关 键 词：多囊卵巢综合征 PAPP-A fβ-HCG 绒毛外滋养细胞 

分 类 号：R711.75[医药卫生—妇产科学]