Variability in local action potential durations, dispersion of repolarization and wavelength restitution in aged wild-type and Scn5a^＋/- mouse hearts modeling human Brugada syndrome  

作　　者：Gary Tse Sheung Ting Wong Vivian Tse Jie Ming Yeo 

机构地区：[1]Department of Medicine and Therapeutics, Faculty of Medicine, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, Chinese University of HongKong, Hong Kong, China [2]Faculty of Medicine, Imperial College London, London, UK [3]Department of Physiology, McGill University, Quebec, Canada

出　　处：《Journal of Geriatric Cardiology》2016年第11期930-931,共2页老年心脏病学杂志（英文版）

摘　　要：Brugada syndrome is a primary arrhythmia syndrome characterized by loss-of-function mutations in the SCN5A gene, which encodes for the cardiac Na^＋ channel. In affected individuals, the risk of developing malignant ventricular arrhythmias and sudden cardiac death are increased.

关 键 词：BRUGADA Conduction Monophasic action potential Mouse REPOLARIZATION 

分 类 号：Q463[生物学—生理学] S541.9[农业科学—作物学]