REPOLARIZATION

作品数：44被引量：90H指数：5
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相关领域：医药卫生更多>>
相关作者：彭司勋夏国瑾黄文龙阎升李新华更多>>
相关机构：中国药科大学同济医科大学首都医科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《介入放射学杂志》《Chinese Medical Journal》《World Journal of Cardiology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats被引量：1
《Journal of Pharmaceutical Analysis》2024年第11期1625-1644,共20页Junping Zhu Ye Lin Gejing Li Yini He Zhaoli Su Yuanyuan Tang Ye Zhang Qian Xu Zhongliu Yao Hua Zhou Bin Liu Xiong Cai 
funded by grants from the National Natural Science Foundation of China(Grant No.:82274506);the China Postdoctoral Science Foundation(Grant No.:2022M721128);the Science and Technology Innovation Program of Hunan,China(Grant No.:2021RC4035);the Natural Science Foundation of Hunan,China(Grant No.:2023JJ40477);the Open-competing Disciple Construction Project of Hunan University of Chinese Medicine(HNUCM),China(Grant No.:22JBZ003);was financially supported by the Furong Distinguished Scholar Program of Hunan,China(Program No.:XJT[2020]58);the 121 Training Project for Innovative Talents of Hunan,China(Project No.:XRSH[2019]192);the Chinese Academy of Engineering Academician Liang Liu's Workstation Project,China(Project No.:KH[2023]3-23YS001);the World First-class Discipline Incubation Project of HNUCM,China(Project No.:XJF[2022]57)。
Rheumatoid arthritis(RA)is a prevalent autoimmune disease characterized by chronic inflammation and excessive proliferation of the synovium.Currently,treatment options focus on either reducing inflammation or inhibiti...
关键词：Halofuginone hydrobromide Rheumatoid arthritis Nanocomplexes Macrophage polarization Rheumatoid arthritis fibroblast-like SYNOVIOCYTES Adjuvant-induced arthritis 
Macrophage polarization or repolarization in tuberculosis
《Asian Pacific Journal of Tropical Medicine》2024年第10期435-444,共10页Arijeet Samanta Sangita Maity Raghunath Hazra Adithyan Jayaraman Santanu Kar Mahapatra 
Tuberculosis caused by Mycobacterium(M.)tuberculosis remains a global public health threat.Over the last few decades,anti-tubercular research mainly focused on mechanisms of identifying by which activated macrophages ...
关键词：TUBERCULOSIS Macrophage polarization Effector responses Antitubercular immune response 
In situ repolarization of tumor-associated macrophages with synergic nanoformulation to reverse immunosuppressive TME in mouse breast cancer for cancer therapy
《Journal of Pharmaceutical Analysis》2024年第8期1247-1250,共4页Ruhua Luo Zhongyu Yue Qian Yang Honghua Zhang Tian Xie Shuling Wang Qingchang Tian 
supported by Zhejiang Provincial Natural Science Foundation of China(Grant No.:LY20H160008);the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China(Grant No.:LHDMZ22H300001);National Natural Science Foundation of China(Grant No.:82074052).
Cancer immunotherapy is a novel cancer treatment strategy.Studies increasingly demonstrate that the immunosuppressive tumor microenvironment(TME)can inhibit effector T cells from attacking tumor cells[1],a pivotal iss...
关键词：cancer inflammation IMMUNOTHERAPY 
A bioactive nanocomposite integrated specific TAMs target and synergistic TAMs repolarization for effective cancer immunotherapy
《Bioactive Materials》2024年第8期472-485,共14页Wei Gu Wen Guo Zhishuang Ren Yimeng Zhang Meiqi Han Qinfu Zhao Yikun Gao Yuling Mao Siling Wang 
supported by the Liaoning Provincial Department of Education youth project(No.LJKQZ20222355,China).
Reactive oxygen species(ROS)generated from photosensitizers exhibit great potential for repolarizing immunosuppressive tumor-associated macrophages(TAMs)toward the anti-tumor M1 phenotype,representing a promising canc...
关键词：Ginseng-derived exosome Colloidal mesoporous silica nanoparticles Tumor-associated macrophages TAMs-specific targeting delivery Repolarizing TAMs 
Nanoparticles (NPs)-mediated Siglec15 silencing and macrophage repolarization for enhanced cancer immunotherapy被引量：1
《Acta Pharmaceutica Sinica B》2023年第12期5048-5059,共12页Xiaodi Liu Qi Zhang Yixia Liang Shiyu Xiong Yan Cai Jincheng Cao Yanni Xu Xiaolin Xu Ye Wu Qiang Lu Xiaoding Xu Baoming Luo 
supported by the National Natural Science Foundation of China(82171944,81873899,China);the Natural Science Foundation of Guangdong Province(2021A1515012611,China);the National Natural Science Foundation of China(82171952,81801719,China);Postdoctoral Research and Development Fund Project of West China Hospital(2023HXBH063,China).
cell infiltration and proliferation in tumor tissues are the main factors that significantly affect the therapeutic outcomes of cancer immunotherapy.Emerging evidence has shown that interferon-gamma(IFN)could enhance ...
关键词：NANOPARTICLES Tumor-associated macrophages Macrophage repolarization T cell infiltration T cell proliferation Cancer immunotherapy Siglec15 Hepatocellular carcinoma 
PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma Progression被引量：1
《Research》2023年第3期547-563,共17页Jue Tang Jing He Huiqin Guo Huiran Lin Meng Li Tianyou Yang Hai-Yun Wang Di Li Jiabin Liu Le Li Huimin Xia Zhenjian Zhuo Lei Miao 
from National Natural Science Foundation of China(82002635,82002636,and 82173593);Guangzhou Science and Technology Project(202102021227 and 202102020421);Shenzhen Municipal Commission of Science and Technology Innovation(JCYJ20220531093213030)。
The recurrence and metastasis of children with mediastinal neuroblastoma(NB)are also occurred after surgery,chemotherapy,or radiotherapy.Strategies targeting the tumor microenvironment have been reported to improve su...
关键词：interferon inhibited specialized 
Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor-associated macrophages被引量：4
《Acta Pharmaceutica Sinica B》2023年第8期3471-3488,共18页Fan Tong Haili Hu Yanyan Xu Yang Zhou Rou Xie Ting Lei Yufan Du Wenqin Yang Siqin He Yuan Huang Tao Gong Huile Gao 
supported by the National Natural Science Foundation of China(82173762,China);the Key Research and Development Program of Science and Technology Department of Sichuan Province(2022YFS0334,2022JDJQ0500,China);111 Project(B18035,China);the Fundamental of Research Funds for the Central Universities。
As known,the benefits of photothermal therapy(PTT)are greatly limited by the heat tolerance of cancer cells resulting from overexpressed heat shock proteins(HSPs).Then HSPs further trigger the formation of stress gran...
关键词：Hollow coppersulfide nanoparticles Sensitized PTT SG inhibition TAMs repolarization pH-driven targeting Photothermal responsiveness Immunotherapy Anti-metastases 
A Redox-responsive Prodrug Nanogel of TLR7/8 Agonist for Improved Cancer Immunotherapy
《Chinese Journal of Polymer Science》2023年第1期32-39,共8页Kai-Shuo Wang Yu-Feng Jin Qi-Song Tong Yong-Cong Huang Zhen-Lin Gao Sui-Juan Zheng Jing-Yang Zhang Jun Wang Jin-Zhi Du 
the National Natural Science Foundation of China(Nos.51922043,52173122 and 31771091);Guangdong Provincial Program(No.2017GC010304);Science and Technology Planning Project of Ganzhou(No.202101074816);Fundamental Research Funds for Central Universities.
The existence of tumor immunosuppressive microenvironment(TIME)is the major determinant for the poor efficacy of current tumor immunotherapy.Tumor-associated macrophages(TAMs)tend to become tumor-promoting M2-like phe...
关键词：NANOGEL Drug delivery Tumor-associated macrophage Macrophage repolarization Cancer immunotherapy 
A polyamidoamine(PAMAM)derivative dendrimer with high loading capacity of TLR7/8 agonist for improved cancer immunotherapy被引量：3
《Nano Research》2022年第1期510-518,共9页Jia-Si Wu Jia-Xian Li Na Shu Qi-Jia Duan Qi-Song Tong Jing-Yang Zhang Yong-Cong Huang Si-Yu Yang Zhi-Bin Zhao Jin-Zhi Du 
supported by National Key R&D Program of China(No.2017YFA0205600);Guangdong Natural Science Funds for Distinguished Young Scholar(No.2017A030306018);National Natural Science Foundation of China(Nos.51922043 and 31771091);Guangdong Provincial Programs(Nos.2017ZT07S054 and 2017GC010304);the Science and Technology Program of Guangzhou(No.201902020018),and Fundamental Research Funds for Central Universities.
Tumor associated macrophages(TAMs)tend to exhibit tumor-promoting M2 phenotype and contribute to the development of immunosuppressive microenvironment of solid tumors.Reprograming TAMs from M2 into tumoricidal M1 phen...
关键词：poly(amidoamine)(PAMAM)dendrimer drug delivery tumor-associated macrophage macrophage repolarization cancer immunotherapy 
T Wave Amplitude Deviation as a Participation Marker of Glycolysis in Myocardial Repolarization被引量：1
《World Journal of Cardiovascular Diseases》2019年第5期343-353,共11页Mikhail U. Alekseev Aleksandr M. Alekseev 
Glucose metabolism is essential for heart physiology, especially in ischemic conditions. Anaerobic glycolysis participates along with aerobic fatty acid oxidation in generating energy supply, and the balance is shifte...
关键词：ELECTROCARDIOGRAM T Wave Deviation Blood SUGAR HYPERGLYCEMIA GLYCOLYSIS 
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