NANOGEL

作品数：35被引量：58H指数：4
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相关作者：周剑锋龙思会丁建勋喻发全叶晓东更多>>
相关机构：中国科学技术大学华中农业大学武汉工程大学兰州生物制品研究所有限责任公司更多>>
相关期刊：《Science Bulletin》《Research》《Bioactive Materials》《Agricultural Biotechnology》更多>>
相关基金：国家自然科学基金湖北省自然科学基金国家重点基础研究发展计划天津市自然科学基金更多>>
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Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition
《Chinese Chemical Letters》2024年第11期389-394,共6页Yuanzheng Wang Chen Zhang Shuyan Han Xiaoli Kong Changyun Quan Jun Wu Wei Zhang 
supported by grants from Science and Technology Program of Guangzhou,China(No.201804010146);Guangzhou Science and Technology Program City-University Joint Funding Project(No.2023A03J0001)。
Enhancing the active tumor targeting ability and decreasing the clearance of reticuloendothelial system(RES)are important issues for drug delivery systems(DDSs)in cancer therapy.In recent years,cell membrane camouflag...
关键词：Cell membrane camouflage BIOMIMETIC Gelatin nanogel Drug delivery Tumor therapy 
ROS-sensitive PD-L1 siRNA cationic selenide nanogels for self-inhibition of autophagy and prevention of immune escape
《Bioactive Materials》2024年第11期597-610,共14页Jie Gao Yonghua Zhai Weihong Lu Xianghe Jiang Jingsheng Zhou Lili Wu Longhai Du Chunqing Ou Xinyi Zhang Hanliang He Jian Zhu Zhengbiao Zhang Meiyun Li Yan Wu Xiangqiang Pan 
National Natural Science Foundation of China(No.21971177,82072051);Natural Science Foundation of the Jiangsu Higher Education Institution of China(No.22KJA150004);Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions;Jiangsu Key Laboratory of Advanced Functional Polymers Design and Application,Soochow University;Suzhou Key Laboratory of Macromolecular Design and Precision Synthesis and the Program of Innovative Research Team of Soochow University.
In the field of cancer therapy,inhibiting autophagy has emerged as a promising strategy.However,pharmacological disruption of autophagy can lead to the upregulation of programmed death-ligand 1(PD-L1),enabling tumor i...
关键词：Multicomponent reaction ROS sensitive Cationic nanogel Autophagy inhibition Immune escape 
An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis
《Acta Pharmaceutica Sinica B》2024年第6期2669-2684,共16页Jamie Anne Lugtu-Pe Xuning Zhang Sako Mirzaie Hao Han R.Chang Nour AL-Mousawi Kuan Chen Yongqiang Li Anil Kane Daniel Bar-Shalom Xiao Yu Wu 
supported in part by an Ontario Research Fund-Research Excellence(ORF-RE)grant(Ontario,Canada)in partnership with Patheon by Thermo Fisher Scientific,Natural Sciences and Engineering Research Council(NSERC)of Canada Discovery Grant and Equipment Grants to Xiao Yu Wu,University of Toronto(Canada),Leslie Dan Faculty of Pharmacy Dean's Fund to Jamie Anne Lugtu-Pe,University of Toronto(Canada),Mitacs Accelerate Internship sponsored by Candoo Pharmatech Company Inc.to Xuning Zhang(Canada),NSERC CREATE ContRoL program support to Sako Mirzaie and Hao Han R.Chang(Canada),Ontario Graduate Scholarship(OGS)to Hao Han R.Chang(Canada),and Pharmaceutical Sciences graduate department scholarships to Hao Han R.Chang and Kuan Chen,University of Toronto(Canada).
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate.However,most new chemical entities exhibit poor water solubility,and he...
关键词：Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions 
Research Progress of Zhuang Medicine Combined with Nanogels in Mastitis
《Agricultural Biotechnology》2024年第2期68-71,共4页Liying XU Chunling YANG Yeting LE Lianzhi TAN Liying TAN Ting LIU 
Supported by Undergraduate Training Program for Innovation and Entrepreneurship of Guangxi University of Chinese Medicine in 2023(S202310600116)。
Mastitis is a common and frequently-occurring disease among Chinese women, which seriously harms their mental and physical health. External application of Zhuang medicine has the effects of dredging collaterals, relie...
关键词：MASTITIS Zhuang medicine NANOGEL OVERVIEW 
Edaravone-loaded poly(amino acid) nanogel inhibits ferroptosis for neuroprotection in cerebral ischemia injury被引量：1
《Asian Journal of Pharmaceutical Sciences》2024年第2期89-101,共13页Yunhan Zhang Zhulin Zou Shuang Liu Fangfang Chen Minglu Li Haoyang Zou Haiyan Liu Jianxun Ding 
supported by the National Natural Science Foundation of China(Grant No.U23A20591,52203201,52173149,and 81971174);the Youth Talents Promotion Project of Jilin Province(Grant No.202019);the Science and Technology Development Program of Jilin Province(Grant No.20210101114JC);Research Cooperation Platform Project of Sino-Japanese Friendship Hospital of Jilin University and Basic Medical School of Jilin University(Grant No.KYXZ2022JC04).
Neurological injury caused by ischemic stroke is a major cause of permanent disability and death. The currently available neuroprotective drugs fail to achieve desired therapeutic efficacy mainly due to short circulat...
关键词：Poly(amino acid)nanogel Controlled drug delivery Inhibition of ferroptosis NEUROPROTECTION Cerebral ischenia injury therapy 
Novel nanogel offers potential treatment for rheumatoid arthritis by trapping and degrading cfDNA
《Rheumatology & Autoimmunity》2023年第3期191-192,共2页Ru Li 
Researchers have developed a novel nanogel that effectively traps and degrades cell-free DNA(cfDNA),a potential cause of rheumatoid arthritis(RA),according to a new study published in Proceedings of the National Acade...
关键词：RHEUMATOID cfDNA POTENTIAL 
A ROS-Sensitive Diselenide-Crosslinked Polymeric Nanogel for NIR Controlled Release
《Chinese Journal of Polymer Science》2023年第3期386-393,I0007,共9页Ji-Chao Hu Qi-Hua Zhang Qiu-Qin Mu Yi-Yuan Tang Zhen Wu Guo-Jie Wang 
financially supported by the National Natural Science Foundation of China (No. 51373025);the Program for New Century Excellent Talents in University (No. NCET-110582)。
Here we report a novel polymeric nanogel with stable loading cargo and near-infrared(NIR) controlled release properties.The nanogels are crosslinked by quaternization reactions of biocompatible poly(β-amino esters) a...
关键词：NANOGELS NIR responsiveness Diselenide-crosslinked Controlled release 
A Redox-responsive Prodrug Nanogel of TLR7/8 Agonist for Improved Cancer Immunotherapy
《Chinese Journal of Polymer Science》2023年第1期32-39,共8页Kai-Shuo Wang Yu-Feng Jin Qi-Song Tong Yong-Cong Huang Zhen-Lin Gao Sui-Juan Zheng Jing-Yang Zhang Jun Wang Jin-Zhi Du 
the National Natural Science Foundation of China(Nos.51922043,52173122 and 31771091);Guangdong Provincial Program(No.2017GC010304);Science and Technology Planning Project of Ganzhou(No.202101074816);Fundamental Research Funds for Central Universities.
The existence of tumor immunosuppressive microenvironment(TIME)is the major determinant for the poor efficacy of current tumor immunotherapy.Tumor-associated macrophages(TAMs)tend to become tumor-promoting M2-like phe...
关键词：NANOGEL Drug delivery Tumor-associated macrophage Macrophage repolarization Cancer immunotherapy 
Microenvironment-responsive chemotherapeutic nanogels for enhancing tumor therapy via DNA damage and glutathione consumption被引量：1
《Chinese Chemical Letters》2022年第9期4197-4202,共6页Mengjie Ye Yuan Gao Mengyun Liang Wei Qiu Xian bin Ma Jiming Xu Junfeng Hu Peng Xue Yuejun Kang Zhigang Xu 
financially supported by the Chongqing Graduate Program of Research and Innovation (No. CYS21110);the National Natural Science Foundation of China (Nos. 51703187, 32071375);Chongqing Talents of Exceptional Young Talents Project, China (Nos. CQYC202005029 and cstc2021ycjh-bgzxm0061)
Although targeted therapy and immunotherapy are now shining in the treatment of some cancers,chemotherapy is still the cornerstone of drug treatment for many cancer patients.The emergence of chemotherapy prodrugs can ...
关键词：NANOGEL PRODRUG GSH-responsive DNA damage Chemotherapy 
Enhancing cancer chemo-immunotherapy by biomimetic nanogel with tumor targeting capacity and rapid drug-releasing in tumor microenvironment被引量：1
《Acta Pharmaceutica Sinica B》2022年第5期2550-2567,共18页Lihuan Shang Xue Jiang Ting Yang Hongbo Xu Qi Xie Mei Hu Conglian Yang Li Kong Zhiping Zhang 
supported by National Natural Science Foundation of China (81673374,China);Program for HUST Academic Frontier Youth Team (2018QYTD13,China);Natural Science Foundation of Hubei Province (2020CFB301,China)。
In the development of chemo-immunotherapy, many efforts have been focusing on designing suitable carriers to realize the co-delivery of chemotherapeutic and immunotherapeutic with different physicochemical properties ...
关键词：CHEMO-IMMUNOTHERAPY NANOGEL PH-RESPONSIVE Cancer cell membrane BIOMIMETIC 
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