A ROS-Sensitive Diselenide-Crosslinked Polymeric Nanogel for NIR Controlled Release  

作　　者：Ji-Chao Hu Qi-Hua Zhang Qiu-Qin Mu Yi-Yuan Tang Zhen Wu Guo-Jie Wang 

机构地区：[1]School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,China [2]Keiraku Display Technology Co.,LTD.,Suzhou 215614,China

出　　处：《Chinese Journal of Polymer Science》2023年第3期386-393,I0007,共9页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (No. 51373025);the Program for New Century Excellent Talents in University (No. NCET-110582)。

摘　　要：Here we report a novel polymeric nanogel with stable loading cargo and near-infrared(NIR) controlled release properties.The nanogels are crosslinked by quaternization reactions of biocompatible poly(β-amino esters) and diselenide-bonded crosslinker(DSe DCl) in microemulsions.The hydrophobic cavities of the nanogels have the property of stably encapsulating the hydrophobic guest molecules,resulted from the crosslinked network structure.Due to the redox responsiveness of the diselenide bonds on the DSe DCl crosslinker,the nanogels can respond to oxidant H_(2)O_(2) causing the disintegration of the crosslinked network structure,thus the encapsulated guest cargo molecules will be released.It is noted that,upon loading the photosensitizer IR780,the nanogels can generate reactive oxygen species(ROS) under NIR irradiation to release the cargo.The advantages of encapsulated cargo stability enhanced by chemical cross-linking and remote stimulation response performance via NIR offer great potential of nanogels for applications of cargo controlled release.

关 键 词：NANOGELS NIR responsiveness Diselenide-crosslinked Controlled release 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]