Microenvironment-responsive chemotherapeutic nanogels for enhancing tumor therapy via DNA damage and glutathione consumption  

作　　者：Mengjie Ye Yuan Gao Mengyun Liang Wei Qiu Xian bin Ma Jiming Xu Junfeng Hu Peng Xue Yuejun Kang Zhigang Xu 

机构地区：[1]Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University),Ministry of Education,School of Materials and Energy and Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices,Southwest University,Chongqing 400715,China [2]Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158,China

出　　处：《Chinese Chemical Letters》2022年第9期4197-4202,共6页中国化学快报（英文版）

基　　金：financially supported by the Chongqing Graduate Program of Research and Innovation (No. CYS21110);the National Natural Science Foundation of China (Nos. 51703187, 32071375);Chongqing Talents of Exceptional Young Talents Project, China (Nos. CQYC202005029 and cstc2021ycjh-bgzxm0061)

摘　　要：Although targeted therapy and immunotherapy are now shining in the treatment of some cancers,chemotherapy is still the cornerstone of drug treatment for many cancer patients.The emergence of chemotherapy prodrugs can improve the drug activity and reduce the side effects of chemotherapy.When used,the tumor microenvironment has characteristics different from normal tissues,and the existence of the microenvironment provided a more convenient way to design responsive nanodrugs.Herein,we designed a glutathione(GSH)-responsive prodrug nanogels for enhancing tumor chemotherapy.In the nanogels of HHNP,10-hydroxycamptothecin(HCPT)played an essential role in killing cancer cells.HCPT was jointed with a cross-linker agent with disulfide bond and was further coated with polyethylene glycol,which not only prolonged the half-life of the drug,but also made HCPT accurate transport to the tumor fractions and achieved precise and controllable release.The proposal of HHNP effectively retained the biological activity of the drug,and introduced functions such as targeting,selective release and biodegradation,which greatly improved the medical efficiency of the drug and effectively reduced the toxic and side effects.This chemotherapeutic prodrug nanogel offers a new window for constructing efficient drug delivery platform.

关 键 词：NANOGEL PRODRUG GSH-responsive DNA damage Chemotherapy 

分 类 号：R730.5[医药卫生—肿瘤] TQ427.26[医药卫生—临床医学] TQ460.4[化学工程]