Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition  

作　　者：Yuanzheng Wang Chen Zhang Shuyan Han Xiaoli Kong Changyun Quan Jun Wu Wei Zhang 

机构地区：[1]Department of Orthopedics,Guizhou Provincial People's Hospital,Guiyang 550000,China [2]Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments(Sun Yat-sen University),School of Biomedical Engineering,Sun Yat-sen University,Guangzhou 510006,China [3]Department of Nephrology,Center of Kidney and Urology,The Seventh Affiliated Hospital,Sun Yat-sen University,Shenzhen 518107,China [4]Bioscience and Biomedical Engineering Thrust,The Hong Kong University of Science and Technology(Guangzhou),Guangzhou 511400,China [5]Division of Life Science,The Hong Kong University of Science and Technology,Hong Kong SAR 999077,China [6]Department of Outpatient,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China

出　　处：《Chinese Chemical Letters》2024年第11期389-394,共6页中国化学快报（英文版）

基　　金：supported by grants from Science and Technology Program of Guangzhou,China(No.201804010146);Guangzhou Science and Technology Program City-University Joint Funding Project(No.2023A03J0001)。

摘　　要：Enhancing the active tumor targeting ability and decreasing the clearance of reticuloendothelial system(RES)are important issues for drug delivery systems(DDSs)in cancer therapy.In recent years,cell membrane camouflage,as one of the biomimetic modification strategies,has shown huge potential.Many natural properties of source cells can be inherited,allowing the DDSs to successfully avoid phagocytosis by macrophages,prolong circulation time,and achieve homologous targeting to lesion tissue.In this study,a cancer cell membrane camouflaged nanoplatform based on gelatin with a typical core-shell structure was developed for cancer chemotherapy.Doxorubicin(DOX)loaded gelatin nanogel(NG@DOX)acted as the inner core,and 4T1(mouse breast carcinoma cell)membrane was set as the outer shell(M-NG@DOX).The M-NG platform enhanced the ability of homologous targeting due to the surface protein of cell membrane being completely retained,which could promote the cell uptake of homotypic cells,avoid phagocytosis by RAW264.7 macrophages,and therefore increase accumulation in tumor tissue.Meanwhile,due to the better controlled drug release capability of M-NG@DOX,premature release of DOX in circulation could be reduced,minimizing side effects in common chemotherapy.As a result,the biomimetic nanoplatform in this study,obtained by a cancer cell membrane camouflaged drug delivery system,efficiently reached desirable tumor elimination,providing a significant strategy for effective targeted therapy and specific carcinoma therapy.

关 键 词：Cell membrane camouflage BIOMIMETIC Gelatin nanogel Drug delivery Tumor therapy 

分 类 号：TQ427.26[化学工程] TB383.1[一般工业技术—材料科学与工程] R730.5[医药卫生—肿瘤]