SYNOVIOCYTES

作品数：21被引量：77H指数：5
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相关作者：陈利峰陈芳刘琴王丽平张宜更多>>
相关机构：广州军区武汉总医院北京协和医院重庆大学更多>>
相关期刊：《Journal of Pharmaceutical Analysis》《实验动物与比较医学》《Journal of Traditional Chinese Medicine》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金广东省自然科学基金安徽省自然科学基金更多>>
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Spatiotemporal Observation of Monosodium Urate Crystals Deposition in Synovial Organoids Using Label-Free Stimulated Raman Scattering
《Research》2025年第1期246-256,共11页Yaxin Chen Ziyi Chen Wenjuan Wang Yinghui Hua Minbiao Ji 
supported by the National Key R&D Program of China(grant numbers 2021YFF0502900 and SQ 2020YFA0803800);the National Natural Science Foundation of China(grant number 82072510);the Shanghai Science and Technology Committee(grant numbers 22dz1204702 and 23dz2260100)。
Gout,a common form of arthritis,is characterized by the deposition of monosodium urate(MSU)crystals in joints.MSU deposition in synovial tissues would initiate arthritis flares and recurrence,causing irreversible join...
关键词：Monosodium urate crystals arthritis flares Stimulated Raman scattering microscopy Spatiotemporal observation Synovial organoids Fibroblast synoviocytes synovial tissues Inflammatory reactions 
Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets被引量：1
《Animal Models and Experimental Medicine》2025年第1期44-56,共13页Lianying Cheng Xiaofeng Rong 
Background : To study the relationships among emodin, synovial fibroblasts (FLSs), and macrophages (STMs) to provide guidance for the use of emodin in rheumatoid arthritis (RA) treatment. Methods : RA clinical samples...
关键词：EMODIN fibroblast synoviocytes MACROPHAGES rheumatoid arthritis 
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats被引量：1
《Journal of Pharmaceutical Analysis》2024年第11期1625-1644,共20页Junping Zhu Ye Lin Gejing Li Yini He Zhaoli Su Yuanyuan Tang Ye Zhang Qian Xu Zhongliu Yao Hua Zhou Bin Liu Xiong Cai 
funded by grants from the National Natural Science Foundation of China(Grant No.:82274506);the China Postdoctoral Science Foundation(Grant No.:2022M721128);the Science and Technology Innovation Program of Hunan,China(Grant No.:2021RC4035);the Natural Science Foundation of Hunan,China(Grant No.:2023JJ40477);the Open-competing Disciple Construction Project of Hunan University of Chinese Medicine(HNUCM),China(Grant No.:22JBZ003);was financially supported by the Furong Distinguished Scholar Program of Hunan,China(Program No.:XJT[2020]58);the 121 Training Project for Innovative Talents of Hunan,China(Project No.:XRSH[2019]192);the Chinese Academy of Engineering Academician Liang Liu's Workstation Project,China(Project No.:KH[2023]3-23YS001);the World First-class Discipline Incubation Project of HNUCM,China(Project No.:XJF[2022]57)。
Rheumatoid arthritis(RA)is a prevalent autoimmune disease characterized by chronic inflammation and excessive proliferation of the synovium.Currently,treatment options focus on either reducing inflammation or inhibiti...
关键词：Halofuginone hydrobromide Rheumatoid arthritis Nanocomplexes Macrophage polarization Rheumatoid arthritis fibroblast-like SYNOVIOCYTES Adjuvant-induced arthritis 
Attenuation of the Activation of NLRP3 Inflammasome in Fibroblast Like Synoviocytes of Rheumatoid Arthritis by Baicalin through Regulating the Let-7i-3p/PI3K/Akt/NF-κB Signaling Axis
《Medicinal Plant》2024年第2期69-73,76,共6页Wei ZHANG Li WANG Yuxin YANG Rui MA Li WANG Ling HUANG Qiaofeng WAN 
Supported by the National Natural Science Foundation of China(82360802):the Natural Science Foundation of Ningxia Province,China(2022AAC 03152).
[Objectives]To study the effect and mechanism of baicalin on the activation of NLRP3 inflammasome in human fibroblast like synoviocytes of rheumatoid arthritis(HFLS-RA).[Methods]To confirm that baicalin alleviated the...
关键词：BAICALIN Rheumatoid arthritis Human fibroblast like synoviocytes of rheumatoid arthritis NLRP3 inflammasome miRNA Dual-luciferase 
CP-25 enhances OAT1-mediated absorption of methotrexate in synoviocytes of collagen-induced arthritis rats被引量：1
《Acta Pharmacologica Sinica》2023年第1期81-91,共11页Chun Wang Hao Tang Yong Wang Yan Chang Yi-jin Wu Bin Wang Wei Sun Feng Xiao Wei Wei 
This work was financially supported by the National Natural Science Foundation of China (grant number 81973332);the Anhui Provincial Natural Science Foundation (grant number 2008085QH402);the Scientific Research Foundation of the Institute for Translational Medicine of Anhui Province (grant number 2017zhyx33);the Enhancement Programme for Basic and Clinical Cooperative Research of Anhui Medical University (grant number 2019xkjT016);the Key Projects of Anhui Province University Outstanding Youth Talent Support Programme (grant number gxyqZD2019017).
Organic anion transporter 1 (OAT1) plays a major role in mediating the absorption, distribution and excretion of drugs and other xenobiotics in the human body. In this study we explored the OAT1 status in rheumatoid a...
关键词：rheumatoid arthritis SYNOVIOCYTE organic anion transporter 1 METHOTREXATE C-25 drug absorption collagen-induced arthritis(CIA)model 
Cold air plasma:A potential strategy for inducing apoptosis of rheumatoid arthritis fibroblast‐like synoviocytes被引量：2
《High Voltage》2022年第1期106-116,共11页Chengbiao Ding Chao Chen Wenchong Ouyang Qi Liu Lin Lin Zhengwei Wu 
supported by the National Natural Science Foundation Incubation Program of the Second Hospital of Anhui Medical University(2020GMFY06);the Key R&D Plan of Anhui Province(201904a07020013);the Natural Science Foundation for Young People of Anhui Medical University(2019XKJ036);the Quality Engineering Project of Anhui Province(2019JYXM0999).
Rheumatoid arthritis(RA)is an autoimmune disease of the joints characterised by synovial hyperplasia and chronic inflammation.Rheumatoid arthritis fibroblast‐like synoviocytes(RA‐FLS)cells are the dominant cell type...
关键词：cytes INFLAMMATION APOPTOSIS 
Activity of fibroblast-like synoviocytes in rheumatoid arthritis was impaired by dickkopf-1 targeting siRNA被引量：5
《Chinese Medical Journal》2020年第6期679-686,共8页Yan-Ying Liu Shi-Yao Wang Ying-Ni Li Wen-Jie Bian Lin-Qi Zhang Yu-Hui Li Li Long Xia Liu Xue-Wu Zhang Zhan-Guo Li 
This work was supported by grants from the National Key R&D Program of China(No.2017YFA0105802);National Natural Science Foundation of China(Nos.81771678,81801617);Peking University People's Hospital Research and Development Funds(No.RDH 2017-02&RDX 2019-02).
Background:Fibroblast-like synoviocytes(FLSs),resident mesenchymal cells of synovial joints,play an important role in the pathogenesis of rheumatoid arthritis(RA).Dickkopf-1(DKK-1)has been proposed to be a master regu...
关键词：DICKKOPF-1 Fibroblast-like SYNOVIOCYTES RHEUMATOID ARTHRITIS small interfering RNAS 
CP-25 reverses prostaglandin E4 receptor desensitization-induced fibroblast-like synoviocyte dysfunction via the G protein-coupled receptor kinase 2 in autoimmune arthritis被引量：11
《Acta Pharmacologica Sinica》2019年第8期1029-1039,共11页Xiao-yi Jia Yan Chang Fang Wei Xing Dai Yu-jing Wu Xiao-jing Sun Shu Xu Hua-xun Wu Chun Wang Xue-zhi Yang Wei Wei 
supported by the National Natural Science Foundation of China (81330081,31200675,81573443,81302845,81603362,81673444,and 81603121);the Anhui Province Natural Science Foundation in the University (KJ2015A317);Anhui Province Natural Science Fund (outstanding youth)(170808J10);Key Projects of Outstanding Young Talent Support Program in Colleges and Universities (gxyqZD2016043)
Paeoniflorin-6’-O-benzene sulfonate (CP-25) is a novel compound derived from paeoniflorin that has been demonstrated to have therapeutic effects in a rat model of rheumatoid arthritis (RA). However, the underlying me...
关键词：adjuvant-induced arthritis paeoniflorin-6'-O-benzene SULFONATE fibroblast-like SYNOVIOCYTES G protein-coupled receptor kinase 2 PROSTAGLANDIN E2 
Efficacy of Zhonglun'a-decoction-containing serum on fibroblastlike synoviocyte apoptosis in rats with collagen-induced arthritis via inhibiting Janus kinase/signal transducer and activator of transcription signaling pathway被引量：5
《Journal of Traditional Chinese Medicine》2019年第2期181-190,共10页Yang Yongsheng Dong Qiumei Ma Chunjie Zhang Yudi Li Yongle Chen Kun Zhang Suo 
Supported by the National Natural Science Foundation of China:to Investigate the Effect and Mechanism of Zhonglun'a-decoction on Immunoregulation and Inducing Synovial Cell Apoptosis in CIA rats(No.81360574)
OBJECTIVE: To investigate the efficacy of Zhonglun'a-decoction-containing serum(ZHONGL-CS)on the in vitro apoptosis of fibroblast-like synoviocytes(FLS) from rats with collagen-induced arthritis(CIA) by investigating ...
关键词：Arthritis rheumatoid SYNOVIOCYTES APOPTOSIS Janus KINASES Zhonglun'a-decoctioncontaining SERUM 
Madecassoside impedes invasion of rheumatoid fibroblast-like synoviocyte from adjuvant arthritis rats via inhibition of NF-κB-mediated matrix metalloproteinase-13 expression被引量：10
《Chinese Journal of Natural Medicines》2018年第5期330-338,共9页YU Wei-Guang SHEN Yong WU Jian-Zhong GAO Yan-Bing ZHANG Li-Xing 
Fibroblast-like synoviocytes(FLS) play a pivotal role in Rheumatoid arthritis(RA) pathogenesis through aggressive migration and invasion. Madecassoside(Madec), a triterpenoid saponin present in Centella asiatica herbs...
关键词：RHEUMATOID ARTHRITIS Fibroblast-like SYNOVIOCYTES MADECASSOSIDE Adjuvant-induced ARTHRITIS Matrix metalloproteinase-13 INVASION 
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