SYNOVIOCYTE

作品数：8被引量：23H指数：3
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相关领域：医药卫生更多>>
相关作者：戴敏郑咏秋沈玉先魏伟更多>>
相关机构：安徽医科大学安徽中医学院重庆大学更多>>
相关期刊：《Genes & Diseases》《Open Journal of Regenerative Medicine》《Journal of Traditional Chinese Medicine》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金广东省自然科学基金安徽省自然科学基金更多>>
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Single-cell RNA sequencing in juvenile idiopathic arthritis
《Genes & Diseases》2024年第2期633-644,共12页Xiwen Luo Xuemei Tang 
supported by grants from the National Key R&D Program of China(No.2021YFC2702003).
Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory rheumatic diseases in children,with onset before age 16 and lasting for more than 6 weeks.JIA is a highly heterogeneous condition with...
关键词：Juvenile idiopathic arthritis MACROPHAGE Macrophage activation syndrome MONOCYTE Single-cell RNA sequencing SYNOVIOCYTE T cell 
CP-25 enhances OAT1-mediated absorption of methotrexate in synoviocytes of collagen-induced arthritis rats被引量：1
《Acta Pharmacologica Sinica》2023年第1期81-91,共11页Chun Wang Hao Tang Yong Wang Yan Chang Yi-jin Wu Bin Wang Wei Sun Feng Xiao Wei Wei 
This work was financially supported by the National Natural Science Foundation of China (grant number 81973332);the Anhui Provincial Natural Science Foundation (grant number 2008085QH402);the Scientific Research Foundation of the Institute for Translational Medicine of Anhui Province (grant number 2017zhyx33);the Enhancement Programme for Basic and Clinical Cooperative Research of Anhui Medical University (grant number 2019xkjT016);the Key Projects of Anhui Province University Outstanding Youth Talent Support Programme (grant number gxyqZD2019017).
Organic anion transporter 1 (OAT1) plays a major role in mediating the absorption, distribution and excretion of drugs and other xenobiotics in the human body. In this study we explored the OAT1 status in rheumatoid a...
关键词：rheumatoid arthritis SYNOVIOCYTE organic anion transporter 1 METHOTREXATE C-25 drug absorption collagen-induced arthritis(CIA)model 
Paeoniflorin-6′-O-benzene sulfonate ameliorates progression of adjuvant-induced arthritis by inhibiting interaction between Ahr and GRK2 of fibroblast-like synoviocytes
《中国药理学与毒理学杂志》2021年第10期777-777,共1页ZHANG Bin-jie WANG Yue-ye JIA Cheng-yan LI Su-su WANG Xin-wei XU Yuan CHEN A-yuan XU He-peng WANG Chun WEI Wei CHANG Yan 
National Nature Science Foundation of China(81573443,82173824,81973332);Anhui Province Natural Science Fund(170808J10);Anhui Provincial Natural Science Foundation(2108085MH320);and Collaborative Innovation Project of Key Scientific Research Platform in Anhui Universities(GXXT-2020-065)。
OBJECTIVE Aryl hydrocarbon receptor(Ahr)is thought to be a crucial factor that regulates immune responses,which may be involved in the pathogenesis of autoimmune inflammation including rheumatoid arthritis(RA).The res...
关键词：aryl hydrocarbon receptor G protein-coupled receptor kinase 2 rheumatoid arthritis CP-25 fibroblasts like synoviocyte adjuvant-induced arthritis 
Efficacy of Zhonglun'a-decoction-containing serum on fibroblastlike synoviocyte apoptosis in rats with collagen-induced arthritis via inhibiting Janus kinase/signal transducer and activator of transcription signaling pathway被引量：5
《Journal of Traditional Chinese Medicine》2019年第2期181-190,共10页Yang Yongsheng Dong Qiumei Ma Chunjie Zhang Yudi Li Yongle Chen Kun Zhang Suo 
Supported by the National Natural Science Foundation of China:to Investigate the Effect and Mechanism of Zhonglun'a-decoction on Immunoregulation and Inducing Synovial Cell Apoptosis in CIA rats(No.81360574)
OBJECTIVE: To investigate the efficacy of Zhonglun'a-decoction-containing serum(ZHONGL-CS)on the in vitro apoptosis of fibroblast-like synoviocytes(FLS) from rats with collagen-induced arthritis(CIA) by investigating ...
关键词：Arthritis rheumatoid SYNOVIOCYTES APOPTOSIS Janus KINASES Zhonglun'a-decoctioncontaining SERUM 
Inhibition of smoothened decreases proliferation of Synoviocytes in rheumatoid arthritis被引量：9
《Cellular & Molecular Immunology》2017年第2期214-222,共9页Shang-ling Zhu Jian-lin Huang Wei-xiang Peng Dan-chun Wu Min-qi Luo Qiu-xia Li Zhao-xia Li Xiao-xue Feng Fang Liu Ming-xia Wang Wei-qian Chen Nancy Olsen Song Guo Zheng 
This work was supported in part by grants from the National Natural Science Foundation of China （81072480）, from the Natural Science Foundation of Guangdong Province （$2012020010927）, and from the Science and Technology Program of Guangdong Province （2013B021800076） （Jian-lin Huang）; the major projects from Science and Technology Program of Guangzhou City, from the National Natural Science Foundation of Guangdong Province, from the Department of Education of Guangdong Province, and grants from NIH AR059103 and NIH AI084359 （Song Guo Zheng）.
Fibroblast-like synoviocytes （FLSs） contribute to synovial hyperplasia in rheumatoid arthritis （RA）. Smoothened （Smo） is a key component of sonic hedgehog （Shh） signaling and contributes to tumor cell prolifer...
关键词：cell proliferation rheumatoid arthritis smoothened protein sonic hedgehog signaling SYNOVIOCYTE 
Effect of Autologus Platelet-Rich Plasma on IL-6, MMP-3 and MCP-1 Expression in Synoviocytes from Osteoarthritic Patients Knees被引量：1
《Open Journal of Regenerative Medicine》2014年第3期64-72,共9页Chang Ich Hur Cheol Park Hanlou Li Jong Keun Seon Hyun Keun Kim Taek Rim Yoon Eun-Kyoo Song 
Nowadays, some studies reported promising results of platelet-rich plasma (PRP) for the treatment of osteoarthritis (OA). However, the effects of PRP on prevention of osteoarthritis in knee joints have been debated. T...
关键词：Platelet-Rich Plasma Inflammatory Cytokines SYNOVIOCYTE OSTEOARTHRITIS 
Glucosides of Chaenomeles speciosa remit rat adjuvant arthritis by inhibiting synoviocyte activities被引量：7
《Acta Pharmacologica Sinica》2003年第11期1161-1166,1176,共7页戴敏 魏伟 沈玉先 郑咏秋 
Project supported by the Natural Science Foundation of Anhui Province, China, № 00044411.
AIM: To investigate the effects of Glucosides of Chaenomeles speciosa(GCS) on rat adjuvant arthritis(AA) and to clarify the role of synoviocytes in this process. METHODS: Complete Freund's adjuvant was used to induce ...
关键词：Chaenomeles speciosa GLUCOSIDES immunologic adjuvants experimental arthritis synovial membrane INTERLEUKIN-1 tumor necrosis factor prostaglandins E 
Effect of Tongbiling (通痹灵) on the Synoviocyte Function in Adjuvant Arthritis Rats
《Chinese Journal of Integrative Medicine》2000年第1期43-46,共4页陈纪藩 赵会芳 沈晓燕 李颂华 李迎敏 廖世煌 黄仰模 奥西秀树 邱联群 关彤 方永奇 刘晓玲 
ThisprogramwassupportedbytheNatureScienceFounda tionofGuangdongProvince(No.960550)
Objective: To study the effect of Tongbiling (TBL) on the proliferation of synovial fibroblast and interleukin1 (IL1), tumor necrosis factor-α (TNF-α) and prostaglandin E 2 (PGE 2) secreted by synoviocytes in adju...
关键词：adjuvant arthritis synovial membrane cell culture FIBROBLAST cell proliferation CYTOKINE TONGBILING 
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