6种常见的循环肿瘤细胞的分离与富集技术  

6 kinds of common technologies of separating and enriching circulating tumor cells

作　　者：蒋能[1] 崔咏梅[1] 李淑华[1] 郑晓克[1] 杨峥[1] 王连唐[1] 柯尊富[1] 

机构地区：[1]中山大学附属第一医院病理科,广东广州510080

出　　处：《分子诊断与治疗杂志》2017年第1期1-5,共5页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(30900650/H1615;81372501/H1615;81572260/H1615;81172232/H1615;81172564/H162);广东省自然科学基金(2011B031800025;S2012010008378;S2012010008270;S2013010015327;2013B021800126;20090171120070;9451008901002146;2013B021800126 2015A020214010 and 2013B021800259);高校基本业务青年重点培育(2015ykzd07)

摘　　要：在过去的几十年,循环肿瘤细胞(circulating tumor cells,CTCs)因其在肿瘤的早期诊断、预后判断、疗效评价、靶向药物的开发、个体化治疗中的潜在作用已经受到了广泛的关注和研究。在转移的肿瘤患者中,循环肿瘤细胞被视为一种微创的极具前景的诊断标志和判断预后的重要标志。许多敏感的筛选方法和设备已经应用于血液中循环肿瘤细胞的分离和富集。本文总结了6种CTCs的分离和富集技术以及他们的优缺点,以期为后续更加优化的新技术、新设备的开发提供更多的参考依据,同时也为后续肿瘤的精准医疗带来一些参考。During the past ten years, circulating tumor cells（CTCs） have received enormous attention as potential research direction, because of the potential value in the early diagnosis of cancer, prediction of clinical prognosis, evaluation of therapeutic efficiency, development of targeted drugs, and personalized medicine of malignant cancer. Circulating tumor cells（CTCs） have been regarded as minimally invasive and promising diagnostic and prognostic biomarkers for patients with metastatic tumors. Multiple highly sensitive approaches and devices have been developed to separate and enrich CTCs in the blood. We have summarized 6kinds of separation and enrichment technologies of CTCs with the opportunities and challenges faced during the development of these systems, this article also provides reference frame for an optimized separation and enrichment technology and highlight some directions for the precision medicine of cancer treatment.

关 键 词：循环肿瘤细胞(CTCs) 精准医疗 分离与富集 

分 类 号：R730.4[医药卫生—肿瘤]