中医药治疗胃上皮异型增生分子机制研究概况  

Molecular Mechanisms Research on Chinese Medicine Treatment of Gastric Epithelial Hyperplasia

作　　者：李芳[1] 韩吉[2] 

机构地区：[1]上海中医药大学附属普陀医院中医内科,上海200062 [2]上海中医药大学附属普陀医院中医综合科,上海200062

出　　处：《实用中医内科杂志》2017年第1期87-90,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：上海市普陀区卫生系统自主创新科研资助重点项目(No:15-PT-03)~~

摘　　要：中医药治疗胃上皮异型增生(Gastric epithelial hyperplasia,GED)具有多成分、多靶点、多基因调控的特点,抑制原癌基因(CerbB-2原癌基因、Bcl-2蛋白),调控抑癌基因(p53、p16),下调增殖相关基因(增殖细胞核抗原、Ki67),调节血管内皮细胞因子,影响肿瘤坏死因子-α表达等改善细胞免疫,改善胃黏膜炎症,达到治疗目的。中药逆转GED机制相当复杂,是多因素综合作用结果,并非是现代药理学某种机制能全部解释的。主要问题①缺乏科学和客观观察指标、疗效评价、诊断及辨证施治标准;②缺乏符合RCT设计及大样本多中心临床研究;③远期疗效不明,随访研究较少提及。Traditional Chinese medicine（TCM） treatment of Gastric epithelial hyperplasia （GED） has the char-acteristics of multiple components, multiple targets, gene regulation, inhibition of proto-oncogenes （CerbB-2 proto-oncogenes, Bcl-2 protein）.By inhibiting the proto-oncogene （CerbB-2 proto-oncogenes, Bcl-2 protein）, regulation of tumor suppressor genes （p53, and p16）, lower proliferation related genes （Proliferating cell nuclear antigen and Ki67）, regulating vascular endothelial cell factors, as well as influence the expression of tumor necrosis factor alpha to improve cellular immunity, improve gastric mucosa inflammation, TCM attain the goal of treatment. TCM reversing GED mechanism is very complex, is more as a result of all kinds of factors, which not the modern pharmacological mechanisms can explain. Main problems： （1） lack of scientific and objective observation indexes, curative effect evaluation, diagnosis and evidence-based medicine standards; （2） lack of accord with RCT design and large sample multi-center clinical research;（3） the long-term curative effect of unknown, follow-up study is less mentioned.

关 键 词：胃上皮异型增生 胃脘痛 痞满 呃逆 嘈杂 积聚 中医药治疗 分子机制 原癌基因 CERBB-2 Bcl-2 抑癌基因 p53 p16 增殖相关基因 增殖细胞核抗原 Ki67 血管内皮细胞因子 肿瘤坏死因子-α 

分 类 号：R735.2[医药卫生—肿瘤]