胆囊癌中B7-H1和B7-H4的表达及临床意义  

Expression of B7-H1 and B7-H4 in Gallbladder Cancer and Their Significance

作　　者：展鹏远[1] 王晓磊[1] 郭伟[1] 金家岩[1] 段文飞[1] 皇甫深强[1] 

机构地区：[1]河南大学第一附属医院,河南开封475001

出　　处：《肿瘤学杂志》2017年第2期130-133,共4页Journal of Chinese Oncology

基　　金：开封市科技发展计划项目(130351)

摘　　要：[目的]探讨胆囊癌中B7-H1和B7-H4的表达及其临床意义。[方法]应用免疫组织化学SP法检测60例胆囊癌组织中B7-H1、B7-H4的表达,分析两者与胆囊癌临床病理特征的关系。[结果]B7-H1和B7-H4在胆囊癌中的阳性表达率显著高于癌旁组织(46.7%vs5.0%,55.0%vs 0)(P均<0.05)。B7-H1、B7-H4在Nevin(Ⅳ+Ⅴ)期、淋巴结转移组中的阳性表达率显著高于Nevin(Ⅰ+Ⅱ+Ⅲ)期、无淋巴结转移组(P<0.05),B7-H1、B7-H4与性别、年龄、合并胆囊结石、肿瘤组织学类型及分化程度无相关性(P>0.05)。B7-H1、B7-H4在胆囊癌中表达呈正相关(r=0.30,P<0.05)。[结论]B7-H1和B7-H4可能在胆囊癌的发生发展中起一定的作用。[Objective] To explore the significance of B7-H1 and B7-H4 expression in gallbladder cancer. [Methods] The expressions of B7-H1 and B7-H4 were detected by immunohistochemistry（SP） method in 60 specimens of gallbladder cancer tissues and 20 specimens of tumor-adjacent tissues,and their correlation with the clinicopathologic characteristics of gallbladder cancer were analyzed. [Results] The expressions of B7-H1 and B7-H4 were significant higher in gallbladder cancer tissue than those in tumor-adjacent tissue（46.7% vs 5.0%,55.0% vs 0.0%;P〈0.05）. The expressions of B7-H1 and B7-H4 in gallbladder cancer were positively correlated with each other.The expressions of B7-H1 and B7-H4 were significantly higher in Nevin stage（Ⅳ＋Ⅴ） group and lymph node metastasis group than those in Nevin stage（Ⅰ＋Ⅱ＋Ⅲ） group and lymph node metastasis-free group,respectively（P 〈0.05）,but they had no correlations with age,sex,complicated cholelithiasis,histological types or tumor differentiation（P〉0.05）. [Conclusion] B7-H1 and B7-H4 may play a role in the occurrence and development of gallbladder cancer. It might provide new means of immunotherapy and gene therapy for gallbladder cancer.

关 键 词：胆囊肿瘤 B7-H1 B7-H4 免疫组织化学 

分 类 号：R735.8[医药卫生—肿瘤]