长春瑞宾联合不同铂类治疗非小细胞肺癌的疗效比较  

Efficacy comparative analysis of vinorelbine combined with different platinum on non-small cell lung cancer

作　　者：李培云[1] 樊变兰[1] 王莉[1] 

机构地区：[1]山西省肿瘤医院,太原030001

出　　处：《中国实用医刊》2017年第4期32-34,共3页Chinese Journal of Practical Medicine

摘　　要：目的：比较长春瑞宾分别与顺铂、奈达铂、卡铂联合治疗非小细胞肺癌的效果差异。方法选取初步确诊为非小细胞肺癌（NSCLC）患者120例，随机分为三组，每组40例，分别应用长春瑞宾﹢顺铂（NP），长春瑞宾﹢奈达铂（NN）及长春瑞宾﹢卡铂（NC）治疗，以3~4周为一疗程，连续进行4个疗程。结果总有效率为 NP组45.0%，NN 组为37.5%，NC 组为45.0%，临床有效率分别为82.5%，72.5%，80.0%，三组近期疗效比较差异未见统计学意义（P ﹥0.05）。NP 组疗法的血小板下降幅度低于其他两组，差异有统计学意义（P ﹤0.05），但 NN 组引起的不良反应较少，对神经系统和肾功能不造成损害。结论长春瑞宾联分别与顺铂、奈达铂、卡铂治疗非小细胞肺癌的近期疗效差异不大，但与奈达铂的联合治疗方案产生的不良反应明显较少。Objective To compare the efficacy of vinorelbine combined with cisplatin,nedapla-tin and carboplatin,respectively on non-small cell lung cancer. Methods A total of 120 patients diag-nosed with non-small cell lung cancer（ NSCLC）were selected,and they were randomly divided into three groups,with 40 patients in each group. They received vinorelbine ﹢ cisplatin（NP）,vinorelbine ﹢nedaplatin（NN）and vinorelbine ﹢ carboplatin（NC）respectively. They were all treated with a course of 3 - 4 weeks for four consecutive cycles. Results The total effective rates of the three groups were：NP group 45. 0% ,NN group 37. 5% ,NC group 45. 0% ,and the clinical efficiency were 82. 5% ,72. 5% , 80. 0% ,the short-term effect had no significant difference among the three groups（ P ﹥ 0. 05 ）. The platelet level in NP group decreased less than the other two groups,the differences were significant＆amp;nbsp;（P ﹤ 0. 05）,but fewer adverse reactions was found in NN group,had no damage on nervous system and kidney function. Conclusions The effects of vinorelbine and cisplatin,nedaplatin,carboplatin respec-tively on non-small cell lung cancer are not significantly different,but vinorelbine combined with nedapl-atin has significantly fewer adverse reactions.

关 键 词：长春瑞宾 铂类药物 非小细胞肺癌 疗效 

分 类 号：R734.2[医药卫生—肿瘤]