奥施康定治疗中重度癌性疼痛57例临床分析  

Clinical observation of oxycontin in treatment of 57 patients with moderate and severe cancer pain

作　　者：纪华清[1] 桂宏亮[1] 李兴保[1] 王辉[1] 

机构地区：[1]安徽省铜陵市人民医院肿瘤一科,铜陵244000

出　　处：《临床医学》2017年第1期33-35,共3页Clinical Medicine

摘　　要：目的观察奥施康定个体化治疗中重度癌性疼痛的疗效及不良反应。方法评估57例中重度癌性疼痛患者的疼痛程度,进行剂量滴定,确定不同患者口服不同剂量奥施康定的止痛效果,观察不良反应。结果 57例中重度癌性疼痛患者口服奥施康定剂量10~220 mg/次,每12小时1次。疼痛完全缓解39例(68.4%),部分缓解16例(28.0%),轻微缓解2例(3.5%),总疼痛显效率为96.5%,其中中度疼痛显效率为100.0%,重度疼痛显效率为89.5%。患者不良反应轻微,主要不良反应为便秘,其次为恶心、呕吐、腹胀、厌食、头晕、排尿困难和嗜睡。结论奥施康定个体化治疗中重度癌性疼痛有效安全,不良反应轻微。Objective To observe the curative effect and adverse reaction of oxycontin in individualized treatment of moderate and severe cancer pain. Methods Fifty-seven patients with moderate and severe cancer pain were enrolled in this study and the degree of their pain was assessed with numerical rating scales（ NRS）. The dose of oxycontin was administrated according to the degree of the patients＇ pain. Results The doses administered were 10-220 mg/times,once every12 hours. Among the 57 patients,39 cases（ 68. 4%） achieved complete remission,16 cases（ 28. 0%） achieved partial remission,and 2 cases（ 3. 5%） achieved minor remission. The total pain relief rate was 96. 5%,the moderate pain relief rate was 100%,and the severe pain relief rate was 89. 5%. The main adverse reactions were constipation,nausea,vomiting,abdominal distension,anorexia,dizziness,dysuria and lethargy. Conclusion Oxycontin in individualized treatment of moderate and severe cancer pain,can significantly improve the quality of life of cancer patients with slight side effects.

关 键 词：奥施康定 癌性疼痛 不良反应 

分 类 号：R730.5[医药卫生—肿瘤]