阿司匹林对老年人大便潜血及结直肠癌检出率的影响  

Influence of aspirin on fecal occult blood test and the detection rate of colorectal cancer in elderly patients

作　　者：谭婉燕[1] 熊枝繁[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院消化科,湖北省武汉市430077

出　　处：《实用老年医学》2017年第2期140-142,共3页Practical Geriatrics

摘　　要：目的观察阿司匹林对老年病人大便潜血试验(FOBT)及结直肠癌检出率的影响,探讨其在结直肠癌化学预防中的作用。方法采用回顾性方法,根据是否长期(≥6月)口服肠溶阿司匹林(100 mg/d),把774例老年病人分为观察组和对照组,比较2组病人的FOBT结果和结直肠癌的检出率。结果观察组和对照组的FOBT阳性率分别为9.5%和5.2%,差异有统计学意义(P<0.05);亚组分析发现,FOBT阳性率在男性和女性间、≥80岁和<80岁老年病人间差异均无统计学意义(P>0.05);观察组和对照组的结直肠癌检出率分别为3.3%和6.4%,差异有统计学意义(P<0.05);亚组分析示结直肠癌检出率在男性和女性、≥80岁和<80岁老年病人间,差异均无统计学意义(P>0.05)。结论在结直肠癌初筛时,长期口服阿司匹林会增加老年病人FOBT阳性率;但病人结直肠癌检出率降低,因而阿司匹林在结直肠癌防治方面可能存在潜在的临床应用价值。Objective To investigate the effect of aspirin on the positive rate of fecal occult blood test（ FOBT） and the detection rate of colorectal cancer in elderly patients,and to explore the effects of aspirin in preventing colorectal cancer. Methods Clinical data of 774 elderly patients in our hospital was analyzed retrospectively. Patients who took aspirin 100 mg / d for a long time（ ≥ 6 months） were enrolled into the observation group; The others were enrolled into control group. The positive rate of FOBT and the detection rate of colorectal cancer were recorded and compared between the two groups.Results The positive rate of FOBT was significantly higher in observation group than that in control group（ P〈0. 05）. Subgroup analysis showed that the difference in the positive rate of FOBT between men and women or between≥80 elderly patients and80 elderly patients was not significant（ P〉0. 05）; The detection rate of colorectal cancer was significantly lower in observation group than that in control group（ P〈0. 05）. Subgroup analysis showed that the difference in the detection rate of colorectal cancer between men and women or between≥80 elderly patients and80 elderly patients was not significant（ P〉0.05）. Conclusions Aspirin can increase the positive rate of FOBT in elderly patients with a longterm use of aspirin,but decrease the detection rate of colorectal cancer,which has a potential clinical value in the prevention and treatment of colorectal cancer.

关 键 词：阿司匹林 老年人 大便潜血试验 结直肠癌 检出率 

分 类 号：R735.3[医药卫生—肿瘤]