脑出血与脑梗死患者血脂及血清脂蛋白谱水平的比较  

Comparison of serum lipid and lipoprotein levels in patients with cerebral hemorrhage and cerebral infarction

作　　者：徐国卫[1] 刘欣[1] 王新成[1] 杨亚红[1] 高兰[1] 郭达云[1] 

机构地区：[1]郑州大学附属郑州中心医院神经内科,450007

出　　处：《中国实用医刊》2017年第3期19-22,共4页Chinese Journal of Practical Medicine

摘　　要：目的：对比分析脑出血与脑梗死患者血脂及血清脂蛋白谱水平差异，为脑出血及脑梗死患者的诊断与防治提供新的思路及理论支持。方法选取2013年2月至2015年3月66例脑血管疾病患者作为研究对象，将其中33例脑梗死疾病患者分为脑梗死组，33例脑出血疾病患者分为脑出血组，另选取33例同期体检健康者作为健康组，采用酶联免疫吸附法及双梯度聚丙烯酰胺凝胶电泳法对三组研究对象肘静脉血样本进行检测，对比观察三组研究对象血脂极低密度脂蛋白（VLDL）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）及三酰甘油（TG）、血清脂蛋白谱脂蛋白 A1（ApoA1）、前β脂蛋白（preβLP）、β脂蛋白（βLP）、α脂蛋白（αLP）及载脂蛋白 B（ApoB）水平。结果脑梗死组及脑出血组 ApoB、VLDL、LDL-C、TC、TG、HDL-C 水平与健康组比较差异均有统计学意义（P ＜0.05）；脑梗死组 HDL-C 及 TC 与脑出血组比较差异有统计学意义（P ＜0.05），两组患者其余各项指标比较差异未见统计学意义（P ＞0.05）。脑梗死组及脑出血组各项指标与健康组比较差异有统计学意义（P ＜0.05）；脑梗死组αLP 水平与脑出血组比较差异有统计学意义（P ＜0.05），两组患者其余各项指标比较差异未见统计学意义（P ＞0.05）。结论血清 TC 及 HDL-C 水平对脑出血及脑梗死疾病辨别率较高，可作为此两种疾病诊断及防治的重要观察指标，具有一定临床价值，值得推广运用。Objective To compare the levels of serum lipids and serum lipoprotein levels in patients with cerebral hemorrhage and cerebral infarction,to provide new ideas and theoretical support for the diagnosis and treatment of cerebral hemorrhage and cerebral infarction patients. Methods Sixty-six patients with cerebrovascular disease from February 2013 to March 2015 were selected as research subjects,33 cases of cerebral infarction were cerebral infarction group,33 cases of cerebral hemorrhage disease were cerebral hemorrhage group,another 33 cases of the same period were selected as health group. The elbow vein blood samples were detected by enzyme linked immunosorbent assay and double gradient polyacrylamide gel electrophoresis in three groups of subjects. The blood lipid in the subjects of the three groups of very low density lipoprotein（VLDL）,low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-L）,total cholesterol（TC）,triglyceride（TG）,serum protein spectrum fat protein A1（ApoA1）,pre beta lipoprotein（preβLP）,beta lipoprotein（βLP）,αlipoprotein （αLP）and apolipoprotein protein B（ApoB）levels were observedhealth group. Results Compared with health group there were significant differences in ApoB,VLDL,LDL-C,TC,TG and HDL-C levels in the cerebral infarction group and cerebral hemorrhage group（ P 0. 05）. Compared with healthy group,the indexes of cerebral infarction group and cerebral hemorrhage group were significantly different（ P 0. 05）. Conclusions The level of serum TC and HDL-C in cerebral hemorrhage and cerebral infarction disease is higher,can be used as an important indicator of the diagnosis and control of the two diseases,has certain clinical value,it is worth popularizing and applying.

关 键 词：脑出血 脑梗死 血脂 血清脂蛋白谱 

分 类 号：R743.3[医药卫生—神经病学与精神病学]