国产靶向刀在≤5cm肝细胞肝癌冷冻消融治疗中的应用  

Safety and efficacy of a Chinamade cryoablation device in treatment of hepatocellular carcinoma smaller than 5cm

作　　者：刘源[1] 李曦[1] 张莉敏[2] 陈婧[3] 蔡懿[4] 林瑶[1] 耿彩娟[1] 王科[1] 王奇奇 何春水[1] 钟森[3] 

机构地区：[1]成都中医药大学附属医院血管外科微创介入治疗中心,四川省成都市610072 [2]成都中医药大学附属医院消化科,四川省成都市610072 [3]成都中医药大学附属医院感染科,四川省成都市610072 [4]成都中医药大学附属医院肿瘤科,四川省成都市610072

出　　处：《世界华人消化杂志》2017年第5期426-431,共6页World Chinese Journal of Digestology

摘　　要：目的评价国产冷冻消融设备在≤5 cm肝细胞肝癌(hepatocellular carcinoma,HCC)消融治疗的安全性及有效性.方法对33例直径≤5 cm HCC,采用国产靶向刀行计算机断层扫描引导下冷冻消融治疗,评估术中、术后手术相关并发症,通过影像学复查评价目标病灶消融效果及术后局部复发率.结果全部33例(共37个病灶)均成功行冷冻消融治疗,消融结束时,消融靶区完全覆盖病灶率为83.78%(31/37),部分覆盖或消融区域达到病灶边缘率为16.22%(6/37).术中、术后无严重并发症出现.平均10.8 mo随访中,32例存活,1例失访,肿瘤病灶局部复发率30.3%(10/33),治疗效果与进口设备相当.结论本研究揭示该国产冷冻消融系统在≤5 cm HCC消融治疗中安全有效,能有效灭活局部瘤体.AIM To assess the safety and efficacy of a Chinamade cryoablation device in the treatment of hepatocellular carcinoma（HCC） smaller than5 cm.METHODS A total of 33 patients with HCC smaller than5 cm were treated by cryoablation using a China-made cryoablation device under the guidance of computed tomography.Operation-associated complications within and after procedures were evaluated.The efficacy of target lesions within procedures and local recurrence rate after procedures were evaluated with imaging modalities.RESULTS All 37 lesions of the 33 patients were successfully treated with a China-made cryablation device.Upon the finish of procedures,complete ablation was achieved in 83.78%（31/37） of lesions,and partial ablation was achieved in16.22%（6/37）.In a median follow-up period of10.8 mo,32 patients remained alive and 1 was lost to follow-up.The rate of local recurrence for target lesions was 30.3%（10/33）,which is equal to that achieved with imported devices.CONCLUSION Our findings suggest that the China-made cryoablation device is safe and effective for HCC smaller than 5 cm with the capability of destroying the whole tumor lesion.

关 键 词：冷冻消融 肝细胞肝癌 国产设备 局部复发率 局部治疗 

分 类 号：R735.7[医药卫生—肿瘤]