慢性胃炎患者焦虑、抑郁状态分析  

Analysis of Anxiety and Depression in Chronic Gastritis Patients

作　　者：张燕[1] 朱婷婷[1] 许倩倩[1] 窦迎春[1] 李青[1] 孟欣颖[1] 周长宏[1] 

机构地区：[1]青岛大学附属青岛市市立医院东院干部保健科,266000

出　　处：《胃肠病学》2017年第2期103-105,共3页Chinese Journal of Gastroenterology

摘　　要：背景:慢性胃炎临床症状反复多样、病程迁延不愈,严重影响患者的生活质量。研究显示情绪障碍对慢性胃炎的发病可能造成一定影响。目的:探讨慢性胃炎患者焦虑、抑郁的发生情况及其与消化道症状、幽门螺杆菌(Hp)感染、胃黏膜炎症程度和炎症活动性的关系。方法:纳入235例慢性非萎缩性胃炎患者,对患者焦虑、抑郁状态、胃肠道症状、胃黏膜炎症程度和炎症活动性进行评估,并检测Hp感染。结果:235例患者中焦虑和(或)抑郁者144例(61.3%);伴焦虑患者108例(46.0%),伴抑郁患者129例(54.9%),同时伴抑郁和焦虑患者93例(39.6%)。伴焦虑和(或)抑郁患者腹痛、腹胀、早饱的发生率、消化道症状积分、Hp阳性率、重度炎症发生率均显著高于无焦虑、抑郁患者(P<0.05),但两组间炎症活动性差异无统计学意义(P>0.05)。结论:慢性胃炎患者中焦虑、抑郁发生率较高,焦虑、抑郁与腹痛、腹胀、早饱消化道症状相关,并可影响胃黏膜炎症程度,患者易伴发Hp感染。Background：Chronic gastritis has varied clinical symptoms and prolonged course, and seriously affects the life quality of patients. Studies have shown that mood disorders might affect the pathogenesis of chronic gastritis. Aims ： To investigate the incidence of anxiety and depression and its relationship with digestive symptoms, Helicobacter pylori （Hp） infection, degree and activity of inflammation in patients with chronic gastritis. Methods： A total of 235 patients with chronic non-atrophic gastritis were enrolled. Anxiety, depression, gastrointestinal symptoms, gastric mucosal inflammation and activity were evaluated, and infection of Hp was detected. Results： In the 235 patients, 144 （61. 3% ） were accompanied by anxiety and/or depression： 108 patients （46.0%） were accompanied by anxiety, 129 patients （54.9%） were accompanied by depression, 93 patients （39. 6% ） were accompanied by anxiety and depression. Incidence of abdominal pain, abdominal distention and early satiety, scores of digestive symptoms, positive rate of Hp infection and incidence of severe inflammation in patients accompanied by anxiety and/or depression were significantly higher than those in patients without anxiety and depression （ P 〈 0.05 ） , but no significant difference in inflammation activity was seen between the two groups （ P 〉 0.05 ）. Conclusions ： Incidence of anxiety and depression in patients with chronic gastritis is high. Anxiety and depression are associated with abdominal pain, abdominal distention and early satiety, and can affect the inflammatory degree of gastric mucosa. Patients with anxiety and depression are susceptible to Hp infection.

关 键 词：胃炎 焦虑 抑郁 消化道症状 炎症 幽门螺杆菌 

分 类 号：R573.3[医药卫生—消化系统] R749[医药卫生—内科学]