128层螺旋CT低剂量灌注成像对鼻咽癌治疗效果评估的临床研究  

Clinic study of low-dose 128-MDCT perfusion imaging in the evaluation of therapeutic effect on nasopharyngeal carcinoma

作　　者：杜涛明[1] 唐烨真[2] 莫云海[1] 冉隆富[1] 

机构地区：[1]成都市第七人民医院CT室,610041 [2]西南民族大学医院放射科

出　　处：《实用医学影像杂志》2017年第1期44-46,共3页Journal of Practical Medical Imaging

摘　　要：目的研究128层螺旋CT低剂量灌注扫描在鼻咽癌放化疗后评估中的临床应用价值。方法将53例经病理证实的鼻咽癌患者(均行放化疗1周期后)随机分成2组,分别进行常规剂量(80 k V,80 m As)和低剂量(80 k V,50 m As)CT灌注扫描,在工作站利用软件对图像进行后处理,测量病变区的血流量(BF)、血容量(BV)和平均通过时间(MTT)等指标,并同时记录患者所受的辐射总剂量。利用配对样本t检验比较2组数据。结果常规剂量与低剂量组的BF、BV值及MTT值差异无统计学意义(P>0.05),低剂量组所接受的辐射剂量明显低于常规剂量组,CT容积剂量指数(CTDIvol)和DLP分别下降了69%和68%。结论 CT低剂量灌注成像可应用于鼻咽癌放化疗后的评估。Objective To study the clinic value of low-dose 128-MDCT perfusion imaging in the evaluation of post-radiotherapy nasopharyngeal carcinoma. Methods Fifty-three cases with nasoparyngeal carcinoma which verified by pathology（all of them were after post-radiotherapy for nearly a week） were divided into two groups randomly, two groups were undergone routine dose（80 k V, 80 m As） and low-dose（80 k V, 50 m As） CT perfusion scanning. The images were processed by perfusion software in the workstation. The value of blood flow（BF）, blood volume（BV）and mean tra-sit time of the lesion′s area were calculated, and the radiation dosage of the patients received,was also calculated.Us-ing the Paired t-test to compare the values of the two groups. Resluts The difference of routine group and low-dose group′s BF, BV and MTT have no statistically signifcant（P〈0.05）,The radiaton dosage of the low-dose group was lower than the routine dose group. The value of CTDIvol and DLP was decreased by 69% and 68%. Conclusion The low-dose CT perfusion imaging could applied in the evaluation of post-radiaton and chemical therapy with nasopharyngeal carcinoma.

关 键 词：体层摄影术 螺旋计算机 辐射剂量 灌注成像 鼻咽肿瘤 

分 类 号：R739.63[医药卫生—肿瘤]