血管内皮生长因子受体-3抗体对人喉鳞癌裸鼠移植瘤生长的影响  

Effect of VEGFR-3 antibody on growth of human laryngeal squamous cell carcinoma xenograft in nude mice

作　　者：李乐[1] 王斌全[2] 田俊[2] 高太虎[1] 

机构地区：[1]山西省肿瘤医院头颈外科一病区,太原030013 [2]山西医科大学第一医院耳鼻咽喉头颈外科

出　　处：《中国药物与临床》2017年第2期168-170,共3页Chinese Remedies & Clinics

摘　　要：目的探讨血管内皮生长因子受体-3(VEGFR-3)抗体对人喉鳞癌裸鼠移植瘤是否具有生长抑制作用。方法利用人喉鳞癌细胞株Hep-2细胞建立裸鼠喉癌模型,分成2组,每组12只,瘤周注射用药。观察肿瘤体积,生长曲线以及抑瘤率。结果 VEGFR-3抗体可以引起荷瘤体积和质量的减少,较0.9%氯化钠注射液对照组差异有统计学意义(t=11.64,P<0.05)。VEGFR-3抗体组抑瘤率为48.21%。结论阻断VEGFR-3受体有望成为喉癌淋巴结转移预防和治疗的潜在靶点。Objective To investigate whether the vascular endothelial growth factor receptor-3（VEGFR-3） antibody can inhibit the growth of human laryngeal squamous cell carcinoma xenograft in nude mice. Methods The human laryngeal squamous carcinoma cell line Hep-2 was used to establish the model of laryngeal carcinoma in nude mice. The mice were divided into two groups（n=12）, and receieved peritumoral injection. The tumor volume, growth curve and tumor inhibition rate were determined. Results VEGFR-3 antibody could induce the decrease of tumor volume and weight, and the differences were statistically significant compared with those in the normal saline control group（t=11.64, P〈0.05）. The tumor inhibition rate in the VEGFR-3 antibody group was 48.21%. Conclusion Blocking VEGFR-3 receptor may be a potential target for the prevention and treatment of lymph node metastasis in laryngeal carcinoma.

关 键 词：喉肿瘤 血管内皮生长因子受体-3 小鼠 近交BALBC 

分 类 号：R739.65[医药卫生—肿瘤]