NF-κB信号介导的慢性炎症与癌症形成的关系  

Relationship between chronic inflammation and cancer intervened by NF-κB pathway

作　　者：刘华[1] 杨春娟[2] 吴高松[1] 王秋红[1] 杨炳友[1] 王知斌[1] 匡海学[1] 

机构地区：[1]黑龙江中医药大学教育部北药基础与应用研究重点实验室/黑龙江省中药及天然药物药效物质基础研究重点实验室,哈尔滨150040 [2]哈尔滨医科大学药学院药物分析与分析化学教研室,哈尔滨150081

出　　处：《实用药物与临床》2017年第2期221-223,共3页Practical Pharmacy and Clinical Remedies

基　　金：国家重点基础研究发展计划(973)项目(2013CB531800);国家自然科学基金资助项目(81573551)

摘　　要：潜在的炎症或炎症形成中微环境的恶性发展致使NF-κB通路激活,激活的NF-κB能够促进细胞因子(IL-6、IL-8、IL-12、IL-17、IL-22、TNF-α、i NOS、COX-2)表达,进而引发结肠癌、前列腺癌、肝癌、淋巴癌等肿瘤形成,表明NF-κB通路在炎症和癌症之间起到了重要的桥梁作用。为明确NF-κB通路在炎症和癌症之间的关系,笔者对相关文献进行综述。Potential inflammation or malignant development of the microenvironment in the formation of inflammation causes the activation of NF-κB pathway,thus promoting the expression of cytokines（included IL-6,IL-8,IL-12,IL-17,IL-22,TNF-α,iNOS and COX-2） and causing the formation of tumors,such as,colon cancer,prostate cancer,liver cancer and lymphoid cancer.It shows that NF-κB pathway plays an important role in the process from inflammation to cancer.The related articles about the relation of NF-κB pathway with the process of inflammation to cancer were reviewed to make clear the relationship.

关 键 词：NF-ΚB 慢性炎症 癌症 

分 类 号：R363[医药卫生—病理学]