以GSK-3β为靶标的miRNAs调控肝细胞癌侵袭转移的研究进展  

Research progress of miRNAs targeting GSK-3β in regulation of hepatocellular carcinoma invasion and metastasis

作　　者：贺松其[1] 文彬[2] 陈冠新[1] 孙海涛[1] 孙嘉玲 杨雪梅[1] 

机构地区：[1]南方医科大学中医药学院,广东广州510515 [2]中国人民解放军四五八医院中医科,广东广州510602

出　　处：《南方医科大学学报》2017年第1期138-140,F0003,共4页Journal of Southern Medical University

基　　金：国家自然科学基金(81573808);广东省中医药局课题(20151038)~~

摘　　要：侵袭转移是导致肝细胞癌高死亡率的关键原因之一,其机制复杂。在肝细胞癌的侵袭转移过程中,miRNAs可作为致癌基因或抑癌基因调节肿瘤细胞的分化、增殖,对肿瘤形成、血管生成及侵袭和转移具有重要影响。本文重点综述了以GSK-3β为靶标的miRNAs调控肝细胞癌侵袭转移的分子机制研究进展,具体涉及到miRNAs与肝细胞癌的细胞增殖、凋亡、侵袭、转移及对GSK-3β的调控作用等相关性研究内容。Invasion and metastasis are key factors contributing to the high mortality rate of patients with hepatocellular carcinoma （HCC） involving a complex mechanism. In the invasion and metastasis of HCC, miRNAs can serve as either oncogenes or tumor suppressor genes to regulate the differentiation and proliferation of tumor cells being and play important roles in tumorigenesis, angiogenesis, invasion and metastasis. This review summarizes the recent progress in research of the molecular mechanisms by which miRNAs targeting GSK-3βregulate HCC invasion and metastasis and examines the roles of miRNAs in hepatocellular carcinoma cell proliferation, apoptosis, invasion, metastasis, and GSK-3βregulation.

关 键 词：肝细胞癌 侵袭转移 MIRNAS 综述 

分 类 号：R735.7[医药卫生—肿瘤]