S100A9蛋白在口腔鳞状细胞癌中的表达及临床意义  

The expression and significance of S100A9 in oral squamous cell carcinoma

作　　者：瞿泽丰 马洪[1] 段晓峰[1] 吴睿[1] 邹苑[1] 

机构地区：[1]贵州医科大学附属口腔医院口腔颌面外科,贵州550004

出　　处：《临床耳鼻咽喉头颈外科杂志》2017年第3期219-222,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：贵州省国际科技合作计划项目[No:黔科合外G字(2014)7009号]

摘　　要：目的:检测人S100钙结合蛋白A9(S100A9)蛋白在口腔鳞状细胞癌(OSCC)组织中的表达,分析其与OSCC临床特征及病理情况的关系,并探讨其在OSCC的早期诊断及预后中的意义。方法:采用免疫组织化学SP法、Western blot检测口腔正常组织标本30例及OSCC标本35例中的S100A9蛋白表达情况。结果:OSCC瘤体组织中S100A9显示为高表达(阳性率77.1%),明显高于正常组织组(阳性率46.7%),二者比较差异有统计学意义(P<0.05);其中中低分化组的表达高于高分化组,Ⅲ~Ⅳ期OSCC组的表达高于Ⅰ~Ⅱ期,以上差异均有统计学意义(P<0.05);S100A9蛋白的表达与患者年龄、性别无关(P>0.05)。结论:S100A9高表达可能在OSCC的发展中发挥十分重要的作用,其表达很可能成为OSCC诊断和预后的分子指标。Objective：This research intended to explore the expression levels of S100A9 protein in oral squamous cell carcinoma（OSCC）,and to analyze its relation with clinicopathologic features in OSCC, then discuss its clinical significance in diagnosis and prognosis of OSCC. Method：Using immunohistochemistry and Western blot to examine S100A9 in 35 oral squamous cell carcinoma specimen and 30 normal oral tissue as control. Result： Expression of S100A9 in oral squamous cell carcinoma（77. 1%）was obviously higher than that in normal organizations （46. 7%）（P〈0.05 ）. Among it, expression of low differentiated group was higher than that of high differentiated group. Expression of oral squamous cell carcinoma group in Ⅲ-Ⅳ period was higher than that of Ⅰ - Ⅱ period. The above differences were statistically significant. Expression of S100A9 was not associated with patients＇age and gender（P〉0.05）. The difference had no statistical significance. Conclusion.. Overexpression of S100A9 protein may play a vital role in the progression of OSCC, which can be served as a positive marker for the diagnosis and prognosis of OSCC.

关 键 词：人S100钙结合蛋白A9 口腔鳞状细胞癌 免疫组织化学 蛋白免疫印迹 

分 类 号：R739.8[医药卫生—肿瘤]