动脉灌注化疗对局部晚期鼻咽癌患者预后及肿瘤标志物的影响  

Analysis of the effect of arterial infusion chemotherapy on the prognosis and tumor markers in patients with locally advanced nasopharyngeal carcinoma

作　　者：彭莉[1] 张露[1] 

机构地区：[1]第三军医大学新桥医院耳鼻咽喉科,重庆400037

出　　处：《中国医学前沿杂志（电子版）》2017年第1期147-150,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨动脉灌注化疗对局部晚期鼻咽癌患者预后及肿瘤标志物的影响。方法选取2008年1月至2012年7月本院收治的局部晚期鼻咽癌患者118例为研究对象,将其随机分为观察组(62例)和对照组(56例),对照组患者给予经静脉诱导化疗联合放疗,观察组患者给予动脉灌注诱导化疗联合同步放化疗。比较两组患者治疗前后血清肿瘤标志物[血清鳞状细胞癌相关抗原(squamous cell carcinoma antigen,SCCAg)、血清铁蛋白(serum ferritin,SF)、细胞角蛋白19片段(cytokeratin 19fragment,CYFRA21-1)]变化情况,随访两组患者治疗后总生存、无远处转移生存及无局部复发生存情况。结果治疗后两组患者血清SCCAg、SF以及CYFRA21-1水平较治疗前均显著降低(P<0.05),且观察组患者SCCAg、SF以及CYFRA21-1水平均显著低于对照组(P<0.05);观察组患者总生存率显著高于对照组(P<0.05),无远处转移生存时间及无局部复发生存时间均显著长于对照组(P<0.05)。结论动脉灌注化疗能够有效降低局部晚期鼻咽癌患者血清肿瘤标志物水平,并有利于改善患者预后。Objective To investigate the effect of arterial infusion chemotherapy on the prognosis and tumor markers in patients with locally advanced nasopharyngeal carcinoma. Method 118 patients with locally advanced nasopharyngeal carcinoma patients treated in our hospital from January 2008 to July 2012 were randomly divided into observation group（62 cases） and control group（56 cases）, patients in control group were given intravenous induction chemotherapy combined with radiotherapy treatment, observation group patients were given arterial perfusion induction chemotherapy combined with concurrent radiotherapy and chemotherapy treatment. Compared the levels of serum tumor markers [squamous cell carcinoma associated antigen（Scc Ag）, serum ferritin（SF）, cytokeratin 19 protein fragment（CYFRA21-1）] before and after treatment between the two groups of patients, followed-up and compared the two groups of patients with overall survival rate, diseasefree survival, free local recurrence free survival rate. Result After treatment, the levels of serum SCCAg, SF and CYFRA21-1 between the two groups were significantly lower than those before treatment（P〈0.05）, and the levels of SCCAg, SF and CYFRA21-1 in observation group were significantly lower than control group（P〈0.05）. There were significantly differences in survival rate, no distant metastasis survival time and no local recurrence survival time between the two groups（P〈0.05）. Conclusion Arterial infusion chemotherapy can effectively reduce the level of serum tumor markers in patients with locally advanced nasopharyngeal carcinoma, and it is beneficial to the prognosis of patients with advanced nasopharyngeal carcinoma.

关 键 词：动脉灌注化疗 局部晚期鼻咽癌 预后 肿瘤标志物 

分 类 号：R739.63[医药卫生—肿瘤]