镉负荷与乳腺癌临床病理特征的关系  

Association between blood cadmium burden and clinicopathological characteristics of breast cancer

作　　者：陈炯玉[1] 黄裔腾[2] 彭裕辉[3] 吴库生[4] 周莉[5] 林雪琼[3] 彭琳[3] 

机构地区：[1]汕头大学医学院附属肿瘤医院肿瘤研究实验室,515041 [2]汕头大学医学院第一附属医院健康管理中心 [3]汕头大学医学院附属肿瘤医院检验科,515041 [4]汕头大学医学院预防医学教研室 [5]汕头大学医学院附属肿瘤医院妇瘤科,515041

出　　处：《国际肿瘤学杂志》2017年第2期91-94,共4页Journal of International Oncology

基　　金：国家自然科学基金（81470152）;广东省科技计划（2014A020212287、2014A020212558）;汕头大学医学院临床研究提升计划（201413）

摘　　要：目的 探讨血镉水平与乳腺癌临床病理特征间的关系.方法 2009年7-12月,收集186例乳腺癌患者外周血标本及临床资料,采用石墨炉原子吸收分光度法测定血镉浓度,利用Mann-Whitney U检验和Kruskal-WallisH检验比较不同临床病理特征间的血镉水平,采用Spearman相关分析评价血镉浓度与临床病理特征的相关性.结果 受调对象血镉水平[M（QR）]为2.280（1.579） μg/L,不同年龄和身体质量指数（BMI）指数的患者间血镉水平差异有统计学意义（Z=-2.075,P=0.038;x2=7.429,P=0.023）.此外,不同T分期（x2=10.137,P=0.017）、M分期（Z=-2.225,P=0.026）、临床分期（x2=16.060,P=0.001）以及人表皮生长因子受体-2（HER-2）表达状态（Z=-2.072,P=0.038）的乳腺癌患者血镉水平差异也具有统计学意义.除年龄外（r =0.126,P=0.066）,BMI、T分期、M分期、临床分期及HER-2与血镉负荷均呈正相关（r=0.159,P=0.030;r =0.171,P=0.020;r =0.166,P=0.044;r =0.154,P=0.040;r =0.152,P=0.038）.结论 乳腺癌患者血镉水平与其临床病理特征存在一定相关性,高血镉负荷可能预示着不良的疾病进展.Objective To explore the association between blood cadmium levels （BCLs） and clinicopathological characteristics of patients with breast cancer.Methods The clinicopathological characteristics and blood specimens of 186 patients diagnosed with breast cancer were collected between July and December 2009.BCLs were detected by graphite-furnace atomizer absorption spectrophotometer.Mann-Whitney U test and Kruskal-Wallis H test were used to compare the BCLs of patients with different clinical characteristics.Spearman rank correlation analysis was used to evaluate the relationships between BCLs and some indices of clinical characteristics.Results The BCLs was 2.280 （1.579） μg/L.The BCLs were significantly different in patients with different age and body mass index （BMI） （Z =-2.075,P =0.038;x2 =7.429,P =0.023）.Also,there were significant differences in different T stages （x2 =10.137,P =0.017）,M stages （Z =-2.225,P =0.026）,clinical stages （x2 =16.060,P =0.001） and human epidermal growth factor receptor-2 （HER-2） status （Z=-2.072,P=0.038）.Excepting for age （r =0.126,P =0.066）,BCLs were positively associated with BMI,T stage,M stage,clinical stage and HER-2 status （r=0.159,P =0.030;r =0.171,P=0.020;r =0.166,P =0.044;r=0.154,P =0.040;r =0.152,P =0.038）.Conclusion The BCLs are associated with some clinicopathological characteristics of breast cancer,and high blood cadmium burden may promote the development of breast cancer.

关 键 词：镉 乳腺肿瘤 病理学 临床 

分 类 号：R737.9[医药卫生—肿瘤]