^(18)F-FDG PET/CT在宫颈癌术后肿瘤标志物升高患者中的应用价值  

Practice Value of ^(18)F-FDG PET/CT in Postoperative Cervical Cancer with Increased Tumor Marker

作　　者：郭佳[1] 谢红军[1] 刘浩[1] 刘兆辉[1] 谢运飞[1] 廖淑惠[1] 任卫萍[1] 

机构地区：[1]四川省医学科学院.四川省人民医院核医学科,四川成都610072

出　　处：《四川医学》2017年第2期231-234,共4页Sichuan Medical Journal

摘　　要：目的探讨^(18)F-脱氧葡萄糖(Fluorine-18 fluorodeoxyglucose,FDG)正电子发射计算机断层显像(Positron Emission Computer Tomography,PET/CT)在宫颈癌术后肿瘤标志物(SCC-Ag,CA125,CEA)升高患者中的应用价值。方法对30例宫颈癌术后肿瘤标志物升高的患者临床资料进行回顾性分析,^(18)F-FDG PET/CT全身显像探测有无复发或/和转移灶,并以病理结果和随访结果为金标准,计算其诊断的灵敏度、特异性、阳性预测值和阴性预测值。随访周期为6~24个月。结果^(18)F-FDG PET/CT诊断宫颈癌术后复发或/和转移22例,其中2例经多次阴道残端组织学病理证实为炎症,1例腹股沟淋巴结经针吸活检病理证实为反应性增生;^(18)F-FDG PET/CT诊断阴性8例,其中1例在随访第12个月时复查PET/CT,显示原摄取FDG稍增高的部位系阴道残端复发,后经病理证实为宫颈癌复发。^(18)F-FDG PET/CT诊断宫颈癌术后复发或/和转移的灵敏度95%(19/20),特异性70%(7/10),阳性预测值86.4%(19/22),阴性预测值87.5%(7/8)。结论^(18)F-FDG PET/CT全身显像能可靠地鉴别肿瘤标志物升高的宫颈癌术后患者有无转移或复发,准确探测复发和转移灶,改变治疗方案。Objective To investigate the practice value of Fluorine-18 fluorodeoxyglucose（^（18）F-FDG） positron Emission Computer Tomography（ PET / CT） in postoperative cervical cancer with increased tumor marker（ SCC-Ag,CA125,CEA）.Methods The clinical data of 30 cases of cervical cancer patients with elevated tumor markers were retrospectively analyzed. Compared the recurrence or metastases denoted by ^（18）F-FDG PET / CT whole body imaging detection with pathological and follow-up results as the gold standard,we calculated the diagnostic sensitivity,specificity,positive predictive value and negative predictive value. The follow-up period was 6 months to 24 months.Results 2 of 22 recurrence or metastases diagnosed by ^（18）F-FDG PET / CT were confirmed as inflammation by pathological examination of vaginal stump and 1 case of those was confirmed to be reactive hyperplasia by needle aspiration biopsy.1 of 8 cases of negative result diagnosed by ^（18）F-FDG PET / CT was confirmed to be cervical cancer recurrence by pathology after 12 months follow-up.The sensitivity,specificity,positive predictive value and negative predictive value were respectively 95%（ 19 / 20）,70%（ 7 / 10）,86. 4%（ 19 / 22） and 87. 5%（ 7 / 8） when diagnosing the recurrence or metastases of cervical cancer by ^（18）F-FDG PET / CT. Conclusion^（18）F-FDG PET / CT whole body imaging could reliably identify and accurately detect the metastasis or recurrence of cervical cancer in patients with elevated tumor markers,and instruct to change the treatment plan.

关 键 词：正电子发射计算机断层显像 18F-氟代脱氧葡萄糖 宫颈癌 SCC-AG CA125 CEA 

分 类 号：R737.33[医药卫生—肿瘤] R730.44[医药卫生—临床医学]