艾司西酞普兰与文拉法辛缓释剂在老年卒中后抑郁治疗中的应用效果对比分析  

Clinical effects of escitalopram and venlafaxine on post-stroke depression in elderly patients

作　　者：马振峰[1] 张金铸[1] 

机构地区：[1]福建福鼎市医院神经内科,福鼎355200

出　　处：《中国实用神经疾病杂志》2017年第2期20-22,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的分析艾司西酞普兰和文拉法辛缓释剂在老年卒中后抑郁患者中的临床治疗效果。方法选取2014-03—2016-05我院诊治的老年卒中后抑郁患者80例,根据治疗措施不同分为对照组和观察组各40例。对照组采用文拉法辛缓释剂治疗,观察组采用艾司西酞普兰治疗,比较2组临床疗效。结果观察组治疗后1周、2周HAMD评分显著低于对照组(P<0.05);观察组不良反应发生率低于对照组(P<0.05)。结论与文拉法辛缓释剂相比,老年卒中后抑郁患者采用艾司西酞普兰治疗效果理想,值得推广应用。Objective To analyze the clinical efficacy of escitalopram versus venlafaxine in the treatment of post-stroke depression in elderly patients.Methods After selecting 80 cases with post-stroke depression from March 2014 to May 2016 treated in our hospital in our study,we divided all cases into observation group which received escitalopram and control group which received venlafaxine,40 cases in each group.Clinical efficacy of two groups were comparatively analyzed.Results One week and two weeks after treatment,the observation group showed less HAMD scores and lower incidence of adverse events compared with the control group（all P〈0.05）.Conclusion Compared with venlafaxine,the clinical efficacy of escitalopram in the treatment of post-stroke depression may be satisfactory and should be widely applied.

关 键 词：艾司西酞普兰 文拉法辛缓释剂 老年卒中 抑郁 

分 类 号：R743.3[医药卫生—神经病学与精神病学]