非典型性脑膜瘤及恶性脑膜瘤预后的相关因素分析  

Prognostic factors for atypical or malignant meningioma post-surgery

作　　者：王宏昭 赵彦标 高超 马琳[2] 王焕宇[2] 黄楹[2] 

机构地区：[1]天津海滨人民医院神经外科,天津300280 [2]天津市环湖医院神经外科十四病区,天津300000

出　　处：《中国实用神经疾病杂志》2017年第3期1-4,共4页Chinese Journal of Practical Nervous Diseases

摘　　要：目的总结非典型性脑膜瘤(atypical meningioma,AM)及恶性脑膜瘤治疗中的经验,分析与其预后相关的主要临床因素。方法整理2004-10—2014-02就诊于我院的96例非典型性及恶性脑膜瘤患者的相关资料,包括性别、年龄等一般资料及远期生活质量评分(Karnofsky performance scale score,KPS评分)、生存期(overall survival,OS)、无进展生存期(progressionfree survival,PFS)、病理结果等。结果 96例患者中68例非典型性脑膜瘤和28例恶性脑膜瘤。80.9%非典型性脑膜瘤患者和67.9%恶性脑膜瘤患者手术达到SimpsonⅠ~Ⅲ级切除;31例(44.1%)非典型性脑膜瘤患者和19例(71.4%)恶性脑膜瘤患者术后进行放疗。中位随访时间25个月,恶性脑膜瘤患者总生存期较非典型性脑膜瘤更短,手术结合术后放疗的无进展生存期长于单纯手术治疗。结论对于非典型性脑膜瘤及恶性脑膜瘤,手术全切肿瘤非常重要,且术后放疗可延长患者生存期。Objective To summarize the experience in managing patients with an atypical or malignant meningioma in our hospital,with a specific focus on determining the prognostic factors for treatment outcome. Methods Ninety-six patients from October 2004 to February 2014 with atypical or malignant meningioma were treated in our hospital. The general material including gender,age and clinical material including Karnofsky Performance Scale score,overall survival,progression-free survival were collected for further study. Results Of all the 96 patients,68 cases were atypical meningioma and 28 cases were malignant meningio- ma. Total resection（Simpson grade Ⅰ -Ⅲ ） was achieved 80.9% of atypical meningioma（n = 52） and 67.9 % of malignant meningioma（n = 12）. 31 （44. 1 % ） patients underwent in the atypical group underwent radiotherapy after surgery, while 19 （ 71.4 % ） patients underwent radiotherapy in the malignant group. The median follow-up duration of all 96 patients was 25 months. The malignant meningioma group had lower overall survival. Progression-free survival for patients in the malignant group who received post- operative radiotherapy was longer than that for those who did not receive radiotherapy. Conclusion Total resection of the tumor is important in the atypical and malignant meningioma groups. Also,radiotherapy after surgery could extend the life of patients.

关 键 词：非典型性脑膜瘤 恶性脑膜瘤 手术治疗 放疗 

分 类 号：R739.41[医药卫生—肿瘤]