早期乳腺癌保乳术后3种调强计划的剂量学比较  

Dosimetric comparison of three intensity- modulated radiotherapy plans in patients following breast-conserving surgery for early-stage breast cancer

作　　者：马兰 韩军[2] 陈秘[2] 曹婷[2] 杨晶[2] 

机构地区：[1]武汉江夏区第一人民医院肿瘤科,湖北武汉430200 [2]华中科技大学同济医学院附属协和医院肿瘤中心,湖北武汉430022

出　　处：《中国医学物理学杂志》2017年第2期151-156,共6页Chinese Journal of Medical Physics

摘　　要：目的:评估早期乳腺癌保乳术后3种调强计划的靶区及其危及器官剂量学指标,为临床选择提供参考。方法:选取10例乳腺癌保乳术后患者(左侧5例,右侧5例),分别设计逆向调强计划、混合调强计划以及野中野调强计划,评估3种方法中靶区和危及器官的剂量学指标。结果:逆向调强计划的均匀性指数和适形指数优于混合调强计划和野中野调强计划,但后两种计划对患侧肺、对侧乳腺、心脏、肝脏等危及器官有更好的保护。结论:混合调强计划和野中野调强计划是早期乳腺癌保乳术后放疗计划的较佳选择。Objective To evaluate the dosimetric parameters of 3 different intensity-modulated radiotherapy（IMRT） plans in postoperative patients receiving breast- conserving surgery for early- stage breast cancer and provide evidence for adequate selection of IMRT plans. Methods The inverse intensity- modulated plan, hybrid intensity- modulated plan and field- in- field intensity-modulated plan were designed for 10 patients after breast-conserving surgery for early-stage breast cancer（including 5 patients with left breast cancer and 5 with right breast cancer）. The dosimetric parameters of the target area and the organs-atrisk（OARs） in the 3 plans were evaluated. Results The heterogeneous index and conformal index of the inverse intensitymodulated plan were superior to those of hybrid and field-in-field intensity-modulated plans, while the protection of ipsilateral lung, contralateral breast, heart and liver was better in the latter two plans. Conclusion The hybrid and field-in-field intensitymodulated plans are recommended for postoperative patients receiving breast-conserving surgery for early-stage breast cancer.

关 键 词：乳腺癌 逆向调强计划 混合调强计划 野中野调强计划 剂量学 

分 类 号：R737.9[医药卫生—肿瘤]