核因子κB与乳腺癌的研究进展  

Research Progress of Nuclear Factor κB and Breast Cancer

作　　者：刘静[1] 秦岩[2] 陈保平[3] 

机构地区：[1]河北大学临床医学院,河北保定071000 [2]河北大学附属医院中心实验室,河北保定071000 [3]河北大学附属医院乳腺外科,河北保定071000

出　　处：《医学综述》2017年第4期675-679,共5页Medical Recapitulate

摘　　要：乳腺癌是威胁全球女性身心健康的主要杀手,其治疗研究已进入到分子信号转导水平。其中,核因子κB(NF-κB)作为一类广泛存在于哺乳动物细胞中不可缺少的信号分子,受到研究者的广泛重视。它不仅在炎症、免疫反应、应激等方面发挥着至关重要的作用,在乳腺癌的发生、发展过程中亦发挥着不可忽视的作用。未来更加明确地了解NF-κB在乳腺癌中的作用机制,对提高乳腺癌患者的存活率具有重要的临床意义。Breast cancer has been a worldwide major killer to women＇ s physical and mental health,and the research and treatment of breast cancer has come to the level of molecular signaling. Nuclear factor kappa B（ NF-κB） as an indispensable signaling molecule widely exists in mammalian cell. After decades of unremitting efforts,it＇ s discovered that NF-κB plays an important role not only in inflammation,immune response,stress response,but also in the occurrence and development of breast cancer. To understand more clearly about the mechanism of NF-κB in breast cancer in the future is of great clinical signficance to improve the survival rate of patients with breast cancer.

关 键 词：乳腺癌 核因子ΚB 靶向治疗 

分 类 号：R737.9[医药卫生—肿瘤]