事件相关电位在三种常见精神疾病中的检查结果分析  

Test results analysis of event-related potentials in three common mental disorders

作　　者：邵春丽[1] 周朝当[1] 

机构地区：[1]云南省红河州第二人民医院电生理室,云南红河654399

出　　处：《中国当代医药》2017年第4期70-73,79,共5页China Modern Medicine

基　　金：云南省红河州第二人民医院科学研究项目(320-57)

摘　　要：目的分析事件相关电位在三种常见精神疾病中的检查结果及在精神疾病诊断中的应用。方法对2015年1月~2016年4月在我院住院或门诊的抑郁症组43例、精神分裂症组53例和慢性酒精中毒组35例患者进行事件相关电位检查,并与健康对照组35名进行比较。比较失匹配负波(MMN)、信息输入(N1)、信息综合(N2)、定向活动(P3a)、认知电位(P3b)在顶(Cz)、额(Fz)两个电极的检查值。结果抑郁症组、精神分裂症组和慢性酒精中毒组患者的Cz、Fz两个电极MMN、N2、P3a、P3b潜伏期延迟均长于健康对照组(MMN-Cz:t=9.15,8.78,10.9;MMN-Fz:t=10.91,8.51,10.25;N2-Cz:t=4.78,6.26,4.01;N2-Fz:t=4.26,4.65,3.97;P3a-Cz:t=8.76,8.52,6.39;P3a-Fz:t=9.30,8.77,6.47;P3b-Cz:t=10.46,11.89,8.13;P3b-Fz:t=9.45,10.37,8.36,P=0.000)。抑郁症组的N1-Cz电极潜伏期延迟短于精神分裂症组(t=2.77,P<0.05)。慢性酒精中毒组的N2-Cz电极潜伏期延迟长于精神分裂症组和抑郁症组(t=2.16,2.73,P<0.05)、P3a-Fz电极潜伏期延迟长于精神分裂症组和抑郁症组(t=8.45,8.54,P<0.01)、P3b-Fz电极潜伏期延迟长于抑郁症组(t=2.61,P<0.05)。P300潜伏期延长等级分布:抑郁症以轻中度延长所占比例较高,精神分裂症组和慢性酒精中毒组以重度延长所占比例较高,差异有统计学意义(u=4.50,2.74,P<0.01、0.05),慢性酒精中毒患者饮酒年限与P3a、P3b-Cz、Fz成高度正相关(r=0.727,0.752,0.734,0.578,P<0.01)。结论抑郁症患者存在MMN明显延迟现象。抑郁症较精神分裂症存在感觉信息输入敏感化现象,抑郁症、精神分裂症和慢性酒精中毒都存在不同程度的信息综合、定向活动、认知电位潜伏期延迟,抑郁症相对较轻,慢性酒精中毒和精神分裂症较重,慢性酒精中毒的额叶最高中枢认知损害最严重。饮酒年限对慢性酒精中毒患者的ERP延迟有明显影响。Objective To analyze the test results of event-related potential in three common mental disorders and their application in the diagnosis of mental diseases.Methods Cases of depression（n=43）,schizophrenia（n=53）,and chronic alcoholism（n =35） from outpatient clinics and inpatient department from January 2015 to April 2016 were given with event-related potential.The test results were compared with those from 35 healthy participants（control group）.The test values of copular（Cz） and frontal（Fz） parts of mismatch negativity（MMN）,information input（N1）,information synthesis（N2）,directional activity（P3a） and cognitive potentials（P3b） were compared.Results The delayed latency of Cz and Fz in MMN,N2,P3 a and P3 b in patients of depression,schizophrenia and chronic alcoholism was significantly longer than that in the healthy control group（ MMN- Cz ： t = 9. 15, 8. 78, 10. 9; MMN- Fz ： t=10. 91, 8. 51, 10. 25; N2- Cz ： t=4. 78,6.26,4.01;N2-Fz：t=4.26,4.65,3.97;P3a-Cz：t=8.76,8.52,6.39;P3a-Fz：t =9.30,8.77,6.47;P3b-Cz：t =10.46,11.89,8.13;P3b-Fz：t =9.45,10.37,8.36,P =0.000）.The delay of latent period for N1-Cz electrode in depression group was shorter than that in schizophrenia group（t=2.77,P0.05）.The delay of latent period for N2-Cz electrode in chronic alcoholism group was longer than that in schizophrenia group and depression group（t=2.16,2.73,P0.05）.In the chronic alcoholism group,the delay of latent period for P3a-Fz electrode was longer than that in schizoph- renia group and depression group（t =8.45,8.54,P〈0.01）,and the delay of latent period for P3b-Fz electrode was longer than that in depression group（t=2.61,P0.05）.P300 latency prolonged grade distribution：depression took the majority of being mild to moderate prolonged,and schizophrenia and chronic alcoholism were in the major of severe prolonging with statistical differences（u=4.50,2.74;P0.01,0.05）.Years of drinking in chronic alcoholism patients has a high positive correlation with P3

关 键 词：事件相关电位 抑郁症 精神分裂症 慢性酒精中毒 MMN P300 潜伏期 延迟 

分 类 号：R749[医药卫生—神经病学与精神病学]