浅谈乳腺癌化疗耐药、转移与微环境  

Introduction to connection between chemotherapy tolerance, metastasis and micro-environment in breast cancer

作　　者：贺智敏[1] 郑国沛[1] 

机构地区：[1]广州医科大学附属肿瘤医院,肿瘤研究所,广州恶性肿瘤治疗转化医学重点实验室,广州510095

出　　处：《中国医师杂志》2017年第2期161-162,共2页Journal of Chinese Physician

摘　　要：本文简要描述了乳腺癌化疗耐药与侵袭转移的相互作用和内在联系；并从乳腺癌上皮间充质转化（EMT）的形成和转归，乳腺癌干细胞的富集和功能分析了耐药和转移发生的共同途径；指出化学治疗在发挥治疗作用的同时可能通过改变肿瘤微环境产生消极作用；提示对肿瘤微环境的理解将有助于制订防止和逆转耐药和转移的研究策略。This review article briefly described the interaction and inner link between chemotherapy tolerance and metastasis of breast cancer. The common pathways of occurrence of drug resistance and metastasis were analyzed with formation and outcome of breast cancer epithelial-mesenehymal transition （EMT） and with enrichment and function of breast cancer stem cells. The chemotherapy which play positive role in clinical practice was pointed out that may cause negative effects by changing tumor microenvironment. Those evidences show that the theory on tumor mieroenvironment will help to formulate the research strategies for preventing and reversing resistance of breast cancer to drug and metastasis.

关 键 词：乳腺肿瘤 药物疗法 药物耐受性 肿瘤侵润 肿瘤转移 述评 

分 类 号：R737.9[医药卫生—肿瘤]