胱氨酸／谷氨酸逆转运体对胶质瘤的作用及麻醉相关应用前景  

The role of cystine/glutamate antiporter on the pathogenesis of glioma and the relative applications of anesthetics

作　　者：王欣悦[1] 王海云[1] 

机构地区：[1]天津医科大学三中心临床学院天津市第三中心医院麻醉科,天津300170

出　　处：《中国医师杂志》2017年第2期319-320,F0003,共3页Journal of Chinese Physician

基　　金：国家自然科学基金资助项目（81071059,81100984,81571054）;天津市应用基础与前沿技术研究计划（一般项目）（15JCYBJC25600）

摘　　要：近年来胶质瘤发病率逐年升高，严重危害人类健康。胱氨酸／谷氨酸逆转运体（systemxc-）是中枢神经系统重要的谷氨酸转运体。在脑肿瘤发生发展的过程中，其表达增多，是近年来关于胶质瘤研究的重点。笔者联系麻醉对胶质瘤的影响，通过探讨systemxc-在胶质瘤发生发展机制中的重要作用，为胶质瘤患者麻醉药物的选择和应用提供新思路。The incidence of glioma has been increasing in recent years, and threatened the human health seriously. Cystine/glutamate antiporter （ system xc - ） is one of the important glutamate transporters in the central nervous system, both the expression of system xc - and the extracellular glutamate concentration increase in the course of brain tumor＇s development. Hence system xc- plays an essential role in the process of brain tumor genesis, it has become an important research field in brain tumor in the past decades. Our present review expound the important role of system xc - in the process of glioma genesis and development as well as provide theoretical foundation and new strategies for the clinical treatment and the application of drugs by connecting with anaesthetics and the effects of system xc - on glioma.

关 键 词：囊泡谷氨酸转运蛋白质类 胱氨酸 神经胶质瘤 麻醉 综述 

分 类 号：R739.41[医药卫生—肿瘤]