上海市青春早期青少年指长比与性发育抑郁及攻击行为关联  

Correlation study of 2D:4D Ratio and sex development,depression and aggressive behavior among young adolescents in Shanghai

作　　者：余春艳[1,2] 左霞云[1] 廉启国[1,2] 齐文娟[1,2] 乐桂珍 汪玲[2] 钟向阳[3] 涂晓雯[1] 楼超华[1] 

机构地区：[1]复旦大学生殖与发育研究院/上海市计划生育科学研究所/国家人口计生委计划生育药具重点实验室,上海200032 [2]复旦大学公共卫生学院/公共卫生安全教育部重点实验室 [3]上海市静安区教育学院

出　　处：《中国学校卫生》2017年第2期238-241,共4页Chinese Journal of School Health

基　　金：上海市卫生和计生委资助项目(20144Y0068);福特基金会资助项目(G66010327)

摘　　要：目的了解青春早期青少年食指(2D)∶无名指(4D)指长比与青春发育、抑郁心理及攻击行为的关联,为探讨生长发育对健康行为及心理的影响提供依据。方法整群抽取上海市某九年一贯制学校10~14岁182名青少年学生参加平板计算机辅助自填问卷调查,了解青少年的身体发育及抑郁心理、攻击行为状况,通过游标卡尺测量被调查者左右手2D和4D指长。结果青春早期青少年女生左右手的2D∶4D指长比均数均高于男生(左手:0.988与0.971;右手:0.996与0.981),差异有统计学意义(t值分别为3.19,3.32,P值均<0.05)。男性青少年变声的发生与左手2D∶4D低指长的关联在10~12岁青少年中已然出现(P=0.035)。男生显现阴茎或睾丸发育、变声等青春发育特征的一组左右手指长比均数均低于未显现特征组,且在13~14岁男性青少年中差异有统计学意义。未检出指长比与抑郁心理及攻击行为有统计学意义的关联。结论低2D∶4D指长比与13~14岁男生青春期发育关联显著。需进一步开展研究以探索其作为小年龄青少年出生前性激素测量指示指标的可能性,建议对双手的2D、4D指长均做测量。Objective To understand whether there are steady sex differences of 2D ： 4D ratio among young adolescents, and to explore the correlation between 2D ： 4D ratio and body development, depression and aggressive behavior. Methods Cluster sampling was taken among adolescents aged 10- 14 years old in a 9-year complementary school. Each adolescent was required to take a Tablet Computer Assisted Self-Interview to report their body development, mental status including depression, as well as health behaviors including aggressive behavior. The length of 2nd digit and 4th digit of both hands were measure by a research assistant through Vernier caliper. A total of 182 adolescents were included in the analysis. Results Both hands of girls＇ 2D ： 4D average ratio were higher than those of boys significantly （ left hand： 0.988 vs 0.971, P = 0.002; right hand： 0.996 vs 0.981, P= 0.001 ）. Earlier voice breaking was correlated with lower 2D ： 4D ratio of left hand among adolescent boy aged 10-12 years old. Boys who were entering puberty showed lower 2D ： 4D ratio than those who were not, with a more significant correlation between left hand 2D ： 4D ratio and the body development such as growth of penis or testes and voice breaking among adolescent boys of 13-14 years old. No correlation was found between 2D ： 4D ratio and depression or aggressive behavior. Conclusion The significant correlation between low 2D ： 4D ratio of both hands and puberty development in young male adolescents might reflect that 2D ： 4D ratio is negatively correlated to high prenatal testosterone. Further studies are needed to testify whether it would be a desirable proxy reflecting sex hormones prior to birth among early adolescents.

关 键 词：生长和发育 抑郁 攻击 青少年 

分 类 号：R179[医药卫生—妇幼卫生保健] R395.6[医药卫生—公共卫生与预防医学]