胚胎停育与焦虑抑郁及孕期生活事件的关系  

The association between embryo damage and anxiety, depression and life events during pregnancy

作　　者：郭立燕[1] 翟敏[2] 刘佳宁[1] 张妍[1] 韩英杰[3] 

机构地区：[1]济宁医学院公共卫生学院流行病学教研室,济宁272067 [2]济宁医学院公共卫生学院社会医学教研室,济宁272067 [3]济宁市第一人民医院产科,济宁272111

出　　处：《中华行为医学与脑科学杂志》2017年第2期167-171,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：山东省高等学校科技计划资助经费项目（J13LK11）;济宁市科技计划（医药卫生）项目（2012jnzh10）

摘　　要：目的研究胚胎停育与焦虑、抑郁及孕期生活事件的关系。方法采用病例对照研究，于2014年3—6月从济宁市两所三甲医院选择192例确诊的胚胎停育孕妇作为病例组，192名同期正常妊娠的孕妇作为对照组。采用焦虑自评量表（SAS），流调用抑郁自评量表（CES—D），孕妇生活事件量表（LESPW）评价两组对象焦虑、抑郁及孕期生活事件情况，分析这些因素与胚胎停育的关系。结果多因素非条件Logistic回归分析结果显示，焦虑（β=0．409，OR=1．050，95％CI=1．003～1．009）、抑郁（β=0．085，OR=1．088，95％CI=1．035—1．145）、孕期生活事件（β=0．003，OR=1．003，95％CI：1．001～1．005）为胚胎停育的危险因素；文化程度（β=-0．749，OR=0．452，95％CI=0．298～0．685）、孕前健康状况（β=-1．366，OR=0．255，95％CI=0．098—0．655）和主动获得优生优育知识（β=-0．884，OR=0．413，95％CI=0．203～0．840）为胚胎停育的保护因素。结论焦虑、抑郁、孕期生活事件与胚胎停育的发生有关，文化程度高、孕前健康状况良好和主动获得优生优育知识可减少胚胎停育的发生。Objective To explore the relationship between embryo damage and anxiety, depression and life events during pregnancy. Methods A case control study was carried out. 192 women diagnosed with embryo damage were selected as the case group, and 192 normal pregnant women or normal parturition within 7 days were selected as the control group from March to June,2014.All cases were from two 3-A-grade general hospitals of Jining. Self-rating anxiety scale （ SAS ） , center for epidemiological survey, depression scale（CES-D） and life events scale for pregnant women（LESPW） were used to evaluate the anxiety, depression and life events of the two groups, so as to analyze the association between these factors and embryo damage. Results Multiple non-conditional logistic regression analysis showed that anxiety （β= 0.409, OR = 1.050,95% CI = 1.003-1.009）,depression（β=0.085, OR= 1.088,95% CI = 1.035-1.145）,life events during pregnancy（β= 0.003, OR= 1.003,95% CI = 1.001-1.005） were the risk factors of embryo damage,while education （ β= - 0.749, OR= 0.452,95 % CI = 0.298-0.685 ）, pre pregnancy health status （β= - 1.366, OR= 0.255,95% CI = 0.098-0.655 ） and taking the initiative to acquire knowledge of eugenics （β= -0.884, OR= 0.413,95% CI =0.203-0.840） were the protective factors of embryo damage. Conclusion Anxiety,depression and life events during pregnancy are related to the occurrence of embryo damage. High degree of education, pre pregnancy in good health and taking the initiative to acquire eugenics knowledge can reduce the oc- currence of embryo damage.

关 键 词：胚胎停育 焦虑 抑郁 孕期生活事件 

分 类 号：R749[医药卫生—神经病学与精神病学] R714.2[医药卫生—临床医学]