补肾中药治疗多发性硬化的研究进展  

Progress of Kidney-Reinforcing Herbs of Traditional Chinese Medicine in Treatment of Multiple Sclerosis

作　　者：郑娜[1,2] 王奇[2] 尹琳琳[1] 

机构地区：[1]首都医科大学宣武医院药物研究室,北京市老年病医疗研究中心,北京市神经药物工程技术研究中心,神经变性病教育部重点实验室,北京100053 [2]广州中医药大学临床药理研究所,广东广州510405

出　　处：《中华中医药学刊》2017年第3期573-575,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81273817);北京市科技新星计划项目(Z12111000250000);北京市卫生系统高层次卫生技术人才项目(2014-3-052)

摘　　要：多发性硬化(multiple sclerosis,MS)是以中枢神经系统炎症性脱髓鞘为主要病理改变的自身免疫性疾病,其主要临床特点为病灶的空间和时间多发性。目前,临床上对MS尚无特效治疗药物,西医主要采用激素、免疫抑制剂等药物治疗,中医主要采用辨证论治的方法加以治疗。根据MS不同的临床表现,中医将MS归属为"痿证"、"痹证"范畴,认为该病病位在"脑与髓"。中医理论认为"肾虚"为本病的根本病因,由于肾主骨生髓,髓汇于脊柱为脊髓、汇于脑为脑髓,在总结前人研究的基础上,从肾虚为本的角度探讨补肾药物对多发性硬化的治疗作用。Multiple sclerosis（MS） is an autoimmune disease of the central nervous system characterized by demyelination and inflammatory lesions. The main clinical features of MS are multiple space and time lesions. There is no speeial treatment for MS in clinical at present. Glucocorticosteroid and immune modulators are often used in MS therapy. However, traditional Chinese medicine differs syndrome and treatment. According to different clinical manifestations of MS, tra- ditional Chinese medicine defines MS belonging to flaccidity or Bi syndrome. The theory of traditional Chinese medicine holds that kidney deficiency is the main pathological mechanism. Reinforcing kidney to replenish marrow by traditional Chinese medicine plays very important roles in the anti - MS effect. On the basis of summarizing previous studies, this review discussed the therapeutic effect of kidney - reinforcing drugs on the treatment of multiple sclerosis.

关 键 词：多发性硬化 补肾中药 治疗 研究进展 

分 类 号：R744.51[医药卫生—神经病学与精神病学]