影响拉莫三嗪治疗儿童癫痫疗效的相关因素分析  

Related Factors of Lamotrigine Treated Epilepsy in Children

作　　者：韩颖[1,2] 张仲斌[1] 王颖慧[1] 王云秀[1] 王丽[1] 张月华[1] 吴晔[1] Han Ying Zhang Zhongbin Wang Yinghui Wang Yunxiu Wang Li Zhang Yuehua Wu Ye(Peking University First Hospital, Beijing 100034, China The General Hospital of Civil Aviation, Be~iing 100025, China)

机构地区：[1]北京大学第一医院,北京100034 [2]民航总医院,北京100025

出　　处：《儿科药学杂志》2017年第3期11-15,共5页Journal of Pediatric Pharmacy

摘　　要：目的:分析拉莫三嗪(LTG)治疗儿童癫痫的疗效及影响疗效的因素。方法:选取2012年5月至2014年11月于北京大学第一医院小儿神经科门诊就诊及病房住院的癫痫患儿为研究对象,回顾性分析应用拉莫三嗪治疗的临床资料,进行疗效评价;分析性别、起病年龄、起病前发育情况、发作类型、加用拉莫三嗪时的病程、单药/添加治疗、血药浓度等对拉莫三嗪疗效的影响。结果:185例患儿纳入研究,无发作率16.2%,有效率38.9%,无效率44.9%,总有效率55.1%;单因素分析显示,起病前发育情况(P=0.002)及发作形式(P=0.072)与拉莫三嗪疗效相关;经多因素分析,仅起病前发育情况与疗效相关[OR=2.67,95%CI(1.39,5.10),P=0.003]。结论:拉莫三嗪治疗儿童癫痫有一定的疗效,患儿起病前发育情况与拉莫三嗪疗效相关。Objective： To investigate the curative effect of lamotrigine（ LTG） treated children epilepsy and analyze the influence factors. Methods： To retrospective analyze the clinical data of epileptic children treated by LTG and statistical analyze the relativity between curative effect and gender,onset of the age,mental development,the types of attacks,the course of disease before using LTG treatment,monotherapy / adjunctive therapy,blood concentration. Results： One hundred and eighty-five cases were collected in outpatient clinics and ward of pediatrics department in Peking University First Hospital from May 2012 to November 2014,with duration of treatment by LTG,no attack rate was 16.2%,effectiveness rate was 38.9%,ineffectiveness rate was 44.9%,the total effectiveness rate was 55.1%. Related factors were mental development before the onset（ P = 0.002） and the types of attacks（ P = 0.072） by single factor analysis. Only mental development before the onset was the factor influencing the LTG efficacy by multiple-factor analysis（ OR = 2.67,95% CI（ 1.39,5.10）,P = 0.003）. Conclusion： LTG makes good efficacy for children epilepsy. Mental development before the onset of epilepsy was the influence factor of the drug efficacy.

关 键 词：拉莫三嗪 儿童 癫痫 单因素 多因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]