LGR5在子宫内膜癌中的表达及其意义  

The Expression and Significance of LGR5 in Endometriai Cancer

作　　者：唐欣然[1] 李小毛[1] TANG Xinran LI Xiaomao(The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou Guangdong 510630, China)

机构地区：[1]中山大学附属第三医院,广东广州510630

出　　处：《实用妇产科杂志》2017年第2期128-131,共4页Journal of Practical Obstetrics and Gynecology

基　　金：国家自然科学基金(编号:30772332);广东省妇幼安康工程-子宫内膜癌防治项目

摘　　要：目的:探讨富含亮氨酸重复序列G蛋白偶联受体5(LGR5)在子宫内膜癌中的表达情况及其与临床病理因素的关系。方法:采用免疫组织化学SABC法检测90例子宫内膜癌及30例正常子宫内膜组织中LGR5表达情况,并分析其与临床病理因素的关系。结果:LGR5在子宫内膜癌组织中的阳性表达率(63.3%)显著高于正常子宫内膜(23.3%)(P<0.001)。LGR5在<1/2肌层浸润组的阳性表达率(72.5%)显著高于≥1/2肌层浸润组(33.3%)(P=0.001)。LGR5的阳性表达率在年龄、病理类型、组织学分级、宫颈累及、淋巴结转移、FIGO分期组间差异均无统计学意义(P>0.05)。多因素分析发现LGR5是子宫内膜癌有无肌层浸润的独立影响因素(OR=0.163,95%CI 0.034~0.772,P=0.022)。结论:LGR5在子宫内膜癌组织中表达上调,提示与肌层浸润深度相关,可能在子宫内膜癌的发生中起一定作用。Objective：To investigate the expression of Leucine-rich repeat-containing G protein-coupled receptor 5 （LGR5） in endometrial cancer（EC） and their relationship with clinicopathological characteristics. Methods： Immunohistochemistry were performed to measure the LGR5 expression in EC（ n =90） and normal endometrium tissue（n = 30）. The expression of LGR5 and its relationship with clinicopathological characteristics were analyzed. Results：The expression of LGR5 was significantly higher in EC than that in normal tissue （63. 3% vs 23.3% ,P〈 0. 001 ）. The expression of LGR5 in 〈 1/2 myometrium infiltration group was higher than in ≥ 1/2 myometrium infiltration group （72.5% vs 33.3%, P = 0.001 ）. There was no significant difference between the expression of LGR5 in different group of age, histological type, histological differentiation, cervical stroma invasion, lymph node metastasis, FIGO stage（ P 〉0.05）. Multivariate analysis showed that LGR5 was an independent in-fluential factor of myometrium infiltration（ OR=O. 163,95%CI 0. 034 -0. 772,P=0. 022）. Conclusions.LGR5 is up-regulated in EC,and is correlated to myometrium infiltration. LGR5 may play an important role in EC tumorigenesis.

关 键 词：富含亮氨酸重复序列G蛋白偶联受体5 子宫内膜癌 肌层浸润 

分 类 号：R737.33[医药卫生—肿瘤]