DNA损伤及氧化应激在放射性心脏损伤中的作用  

The role of DNA damage and oxidative stress in radiation-induced heart disease

作　　者：刘力坤 欧阳伟炜[1,2,3] 苏胜发[1,2,3] 马筑[1,2,3] 李青松[1,2,3] 王羽[1,2,3] 罗大先[1,2,3] 何志旭[4] 卢冰[1,2,3] 

机构地区：[1]贵州医科大学附属医院肿瘤科 [2]贵州省肿瘤医院肿瘤科,贵阳550004 [3]贵州医科大学肿瘤学教研室,贵阳550001 [4]贵州医科大学组织工程及干细胞研究中心,贵阳550001

出　　处：《科技导报》2017年第4期74-78,共5页Science & Technology Review

基　　金：国家自然科学基金地区科学基金项目(81660507);贵州省应用基础研究计划重大专项(黔科合J重大[2015]2003);贵州省科技厅课题(黔科合LH字[2014]7135);贵州省教育厅创新群体重大研究项目(黔教合KY[2016]032)

摘　　要：放射性心脏损伤(RIHD)是放射诱导的一种进行性加重的疾病,它几乎影响心脏所有结构,从而产生一系列心脏并发症。从早期的无症状到慢性心力衰竭,常需几年至十几年时间。近年来文献报道心脏在正常组织耐受剂量控制下,常规胸部放疗所致的心脏损伤,特别是迟发型心肌损伤问题日益突出。本文综述了DNA损伤及氧化应激在RIHD的发生发展中的作用,现有研究认为RIHD可使心脏僵硬度增加、心肌收缩及舒张功能下降,引起心肌电生理紊乱、心律失常、心功能不全甚至猝死。但目前尚缺乏对RIHD的有效治疗,其根本原因在于对RIHD的原因及发病机制尚未完全阐明。The radiation-induced heart disease（RIHD） is a progressive disorder induced by radiation, which may take years or decades to manifest. It can affect various structures of the heart, with a series of cardiac complications. In recent years, it is reported that the heart damage caused by the conventional chest radiotherapy, especially the delayed type of myocardial injuries becomes very serious under the control of the normal tissue tolerance dose. The RIHD can increase the heart stiffness, decrease the myocardial systolic and diastolic functions, resulting in the myocardial electrophysiological dysfunction, the arrhythmia, the heart failure and the sudden death. At present,there is still a lack of effective treatment for the RIHD, the basic reason is that the causes and pathogenesis of the RIHD promoted chronic heart failure from early asymptomatic condition have not been fully clarified. This paper reviews the role of the DNA damage and the oxidative stress in the RIHD to help the prevention and treatment of the RIHD.

关 键 词：放射性心脏损伤 电离辐射 DNA损伤反应 活性氧 

分 类 号：R730.55[医药卫生—肿瘤]