肝硬化门静脉高压导致的胃肠结构和功能改变及其临床表现  

Changes in gastrointestinal structure and function caused by cirrhotic portal hypertension and related clinical manifestations

作　　者：尚祉胤 杨敬貌 陈丽萍[2] 刘敏[1] 程开[1] 李耀华[4] 艾迎春[1] 程计林[2] 

机构地区：[1]佳木斯大学附属第一医院消化科,黑龙江佳木斯154000 [2]上海市公共卫生临床中心消化科,上海201500 [3]温州医科大学,浙江温州325000 [4]复旦大学上海医学院生物化学与分子生物学系,上海201500

出　　处：《临床肝胆病杂志》2017年第2期354-358,共5页Journal of Clinical Hepatology

摘　　要：临床上高达80%的肝硬化门静脉高压患者存在不同程度胃肠症状,这与肝硬化门静脉高压导致的胃肠结构改变、胃肠功能失调及神经体液调节改变有关。回顾了肝硬化门静脉高压对胃肠结构改变、胃肠功能失调及神经体液调节改变的影响,以及这些改变所导致的消化道临床表现,提示对肝硬化门静脉高压胃肠结构改变进行研究,可以有效地预防和治疗肝硬化的并发症,改善胃肠症状;另外,对胃肠功能进行调节,可改善患者症状,有助于延缓肝硬化进展,建议定期内窥镜评估肝硬化患者胃肠黏膜和血管的改变,有助于早期治疗和减少并发症。In clinical practice,up to 80% of patients with cirrhotic portal hypertension have varying degrees of gastrointestinal symptoms,which are associated with the changes in gastrointestinal structure,gastrointestinal dysfunction,and altered neurohumoral regulation.This article reviews the changes in gastrointestinal structure,gastrointestinal dysfunction,and altered neurohumoral regulation caused by cirrhotic portal hypertension,as well as the gastrointestinal clinical manifestations caused by such changes.It is pointed out that the research on the changes in gastrointestinal structure in cirrhotic patients with portal hypertension helps to effectively prevent and treat the complications of liver cirrhosis and improve gastrointestinal symptoms.In addition,the regulation of gastrointestinal function can improve patients＇ symptoms and delay the progression of liver cirrhosis.Therefore,it is recommended to regularly evaluate the changes in gastrointestinal mucosa and vessels in patients with liver cirrhosis,in order to provide early treatment and reduce complications.

关 键 词：肝硬化 门静脉压 胃肠道 综述 

分 类 号：R575.21[医药卫生—消化系统]